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    Ppox protoporphyrinogen oxidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289219, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ppoxprovided by RGD
    Official Full Name
    protoporphyrinogen oxidaseprovided by RGD
    Primary source
    RGD:1310543
    See related
    EnsemblRapid:ENSRNOG00000003567 AllianceGenome:RGD:1310543
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables oxygen-dependent protoporphyrinogen oxidase activity. Involved in heme biosynthetic process; protoporphyrinogen IX metabolic process; and response to xenobiotic stimulus. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in variegate porphyria. Orthologous to human PPOX (protoporphyrinogen oxidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 112.8), Liver (RPKM 73.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ppox in Genome Data Viewer
    Location:
    13q24
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (86230111..86235028, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (83697661..83701998, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (89650094..89654998, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 4 Neighboring gene beta-1,4-galactosyltransferase 3 Neighboring gene ubiquitin specific peptidase 21 Neighboring gene ubiquitin-fold modifier conjugating enzyme 1 Neighboring gene G protein subunit gamma 5, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane  
    located_in mitochondrial inner membrane PubMed 
    located_in mitochondrial inner membrane  
    is_active_in mitochondrial intermembrane space  
    located_in mitochondrial membrane  
    located_in mitochondrion PubMed 

    General protein information

    Preferred Names
    protoporphyrinogen oxidase
    NP_001099438.1
    XP_006250302.1
    XP_006250303.1
    XP_006250305.1
    XP_038946434.1
    XP_038946436.1
    XP_038946437.1
    XP_063128198.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105968.1NP_001099438.1  protoporphyrinogen oxidase

      See identical proteins and their annotated locations for NP_001099438.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473985
      UniProtKB/TrEMBL
      A6JFW5
      Conserved Domains (1) summary
      TIGR00562
      Location:3471
      proto_IX_ox; protoporphyrinogen oxidase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      86230111..86235028 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090506.2XP_038946434.1  protoporphyrinogen oxidase isoform X2

      UniProtKB/TrEMBL
      A6JFW5
      Conserved Domains (1) summary
      TIGR00562
      Location:3471
      proto_IX_ox; protoporphyrinogen oxidase
    2. XM_006250240.5XP_006250302.1  protoporphyrinogen oxidase isoform X1

      See identical proteins and their annotated locations for XP_006250302.1

      UniProtKB/TrEMBL
      D3ZVN7
      Conserved Domains (3) summary
      TIGR00562
      Location:3482
      proto_IX_ox; protoporphyrinogen oxidase
      pfam13450
      Location:765
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:238372
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    3. XM_006250241.4XP_006250303.1  protoporphyrinogen oxidase isoform X1

      See identical proteins and their annotated locations for XP_006250303.1

      UniProtKB/TrEMBL
      D3ZVN7
      Related
      ENSRNOP00000004896.5, ENSRNOT00000004896.8
      Conserved Domains (3) summary
      TIGR00562
      Location:3482
      proto_IX_ox; protoporphyrinogen oxidase
      pfam13450
      Location:765
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl21454
      Location:238372
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    4. XM_006250243.3XP_006250305.1  protoporphyrinogen oxidase isoform X3

      Conserved Domains (2) summary
      TIGR00562
      Location:18427
      proto_IX_ox; protoporphyrinogen oxidase
      cl21454
      Location:183317
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    5. XM_039090508.2XP_038946436.1  protoporphyrinogen oxidase isoform X4

      Conserved Domains (1) summary
      TIGR00562
      Location:45350
      proto_IX_ox; protoporphyrinogen oxidase
    6. XM_063272128.1XP_063128198.1  protoporphyrinogen oxidase isoform X4

    7. XM_039090509.2XP_038946437.1  protoporphyrinogen oxidase isoform X5

      Conserved Domains (1) summary
      COG1232
      Location:5299
      HemY; Protoporphyrinogen oxidase [Coenzyme transport and metabolism]
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