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    Aph1bl2 aph-1 homolog B, gamma secretase subunit like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691658, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aph1bl2provided by RGD
    Official Full Name
    aph-1 homolog B, gamma secretase subunit like 2provided by RGD
    Primary source
    RGD:1597236
    See related
    AllianceGenome:RGD:1597236
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559979
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in Notch signaling pathway; positive regulation of catalytic activity; and protein processing. Predicted to be part of gamma-secretase complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 69.2), Lung (RPKM 68.5) and 9 other tissues See more
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    Genomic context

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    See Aph1bl2 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (76236827..76259012, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (67341790..67363967, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (72472787..72494547, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480068 Neighboring gene uncharacterized LOC120094191 Neighboring gene carbonic anhydrase 12 Neighboring gene aph-1 homolog B, gamma secretase subunit like 1 Neighboring gene aph-1 homolog B, gamma secretase subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Notch receptor processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of gamma-secretase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of gamma-secretase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    similar to anterior pharynx defective 1b homolog
    Names
    gamma-secretase subunit APH-1B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001409174.1 → NP_001396103.1  similar to anterior pharynx defective 1b homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8J8XJD4, Q4G070

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      76236827..76259012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266195.1 → XP_063122265.1  similar to anterior pharynx defective 1b homolog isoform X3

      UniProtKB/TrEMBL
      A0A8I6A315, Q4G070

    2. XM_063266194.1 → XP_063122264.1  similar to anterior pharynx defective 1b homolog isoform X2

    3. XM_063266193.1 → XP_063122263.1  similar to anterior pharynx defective 1b homolog isoform X1

      UniProtKB/TrEMBL
      Q4G070

    4. XM_063266198.1 → XP_063122268.1  similar to anterior pharynx defective 1b homolog isoform X5

    5. XM_063266196.1 → XP_063122266.1  similar to anterior pharynx defective 1b homolog isoform X4

    RNA

    1. XR_010054032.1 RNA Sequence

    2. XR_010054031.1 RNA Sequence

    3. XR_010054033.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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