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    Pom121 POM121 transmembrane nucleoporin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 113975, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pom121provided by RGD
    Official Full Name
    POM121 transmembrane nucleoporinprovided by RGD
    Primary source
    RGD:620680
    See related
    EnsemblRapid:ENSRNOG00000001449 AllianceGenome:RGD:620680
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    A structural constituent of nuclear pore. Involved in nuclear pore organization. Part of nuclear pore. Orthologous to several human genes including POM121 (POM121 transmembrane nucleoporin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 41.4), Thymus (RPKM 38.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pom121 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (26913513..26930861)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (21273713..21294299)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (24316575..24341943)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481281 Neighboring gene uncharacterized LOC120095917 Neighboring gene NOP2/Sun RNA methyltransferase 5 Neighboring gene tripartite motif-containing 50 Neighboring gene FKBP prolyl isomerase family member 6 Neighboring gene uncharacterized LOC120095916

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Correlation between nucleocytoplasmic transport and caspase-3-dependent dismantling of nuclear pores during apoptosis. Kihlmark M, et al. Exp Cell Res, 2004 Feb 15. PMID 14729472
    2. Nuclear pore complexes form immobile networks and have a very low turnover in live mammalian cells. Daigle N, et al. J Cell Biol, 2001 Jul 9. PMID 11448991, Free PMC Article
    3. An integral membrane protein of the pore membrane domain of the nuclear envelope contains a nucleoporin-like region. Hallberg E, et al. J Cell Biol, 1993 Aug. PMID 8335683, Free PMC Article
    4. POM121 and Sun1 play a role in early steps of interphase NPC assembly. Talamas JA, et al. J Cell Biol, 2011 Jul 11. PMID 21727197, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear pore organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nuclear envelope pore membrane protein POM 121
    Names
    P145
    POM121 membrane glycoprotein
    integral membrane glycoprotein
    nuclear pore membrane glycoprotein 121 kD
    nuclear pore membrane protein 121
    nucleoporin Nup121
    pore membrane protein of 121 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053622.2 → NP_446074.2  nuclear envelope pore membrane protein POM 121

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      P52591
      UniProtKB/TrEMBL
      A6J0D1, G3V659
      Related
      ENSRNOP00000001968.1, ENSRNOT00000001968.4
      Conserved Domains (3) summary
      PHA03247
      Location:422 → 761
      PHA03247; large tegument protein UL36; Provisional
      pfam15229
      Location:292 → 527
      POM121; POM121 family
      pfam15967
      Location:911 → 1021
      Nucleoporin_FG2; Nucleoporin FG repeated region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      26913513..26930861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52591.1 GenPept UniProtKB/Swiss-Prot:P52591

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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