U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Cdc40 cell division cycle 40 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361859, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cdc40provided by RGD
    Official Full Name
    cell division cycle 40provided by RGD
    Primary source
    RGD:1307063
    See related
    EnsemblRapid:ENSRNOG00000000581 AllianceGenome:RGD:1307063
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in embryonic brain development and mRNA splicing, via spliceosome. Predicted to be located in nuclear speck. Predicted to be part of U2-type catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 15. Orthologous to human CDC40 (cell division cycle 40). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 100.1), Thymus (RPKM 73.4) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cdc40 in Genome Data Viewer
    Location:
    20q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (45855739..45908239, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (44273080..44325605, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (48503973..48574546)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene D-aspartate oxidase Neighboring gene methyltransferase like 24 Neighboring gene uncharacterized LOC120098819 Neighboring gene uncharacterized LOC120098955 Neighboring gene WASP family member 1 Neighboring gene G protein-coupled receptor 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA binding  
    Process Evidence Code Pubs
    involved_in embryonic brain development  
    involved_in mRNA splicing, via spliceosome  
    involved_in mRNA splicing, via spliceosome  
    Component Evidence Code Pubs
    part_of U2-type catalytic step 2 spliceosome  
    part_of catalytic step 2 spliceosome  
    part_of catalytic step 2 spliceosome  
    located_in nuclear speck  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    pre-mRNA-processing factor 17
    Names
    cell division cycle 40 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394220.1NP_001381149.1  pre-mRNA-processing factor 17

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A0G2JW64, B2RYC1
      Related
      ENSRNOP00000069760.2, ENSRNOT00000077926.3
      Conserved Domains (2) summary
      cd00200
      Location:281579
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:292330
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      45855739..45908239 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279319.1XP_063135389.1  pre-mRNA-processing factor 17 isoform X1

    External link. Please review our privacy policy.