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    Htra2 HtrA serine peptidase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297376, updated on 9-Dec-2024

    Summary

    Official Symbol
    Htra2provided by RGD
    Official Full Name
    HtrA serine peptidase 2provided by RGD
    Primary source
    RGD:1308906
    See related
    EnsemblRapid:ENSRNOG00000022448 AllianceGenome:RGD:1308906
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Prss25
    Summary
    Enables serine-type peptidase activity. Involved in several processes, including ceramide metabolic process; pentacyclic triterpenoid metabolic process; and response to herbicide. Predicted to be located in several cellular components, including chromatin; cytoplasmic side of plasma membrane; and mitochondrial intermembrane space. Predicted to be part of CD40 receptor complex and serine-type endopeptidase complex. Predicted to be active in mitochondrion. Used to study transient cerebral ischemia. Biomarker of asphyxia neonatorum; cryptorchidism; middle cerebral artery infarction; and status epilepticus. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 8; Parkinson's disease; and motor neuron disease. Orthologous to human HTRA2 (HtrA serine peptidase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 178.6), Spleen (RPKM 91.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Htra2 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117114631..117117793, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (115556914..115560202, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (113883671..113886833, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene meiosis 1 associated protein Neighboring gene uncharacterized LOC120102319 Neighboring gene docking protein 1 Neighboring gene lysyl oxidase-like 3 Neighboring gene AUP1, lipid droplet regulating VLDL assembly factor Neighboring gene DEAQ box RNA-dependent ATPase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding  
    enables peptidase activity  
    enables protein serine/threonine kinase inhibitor activity  
    enables serine-type endopeptidase activity  
    enables serine-type endopeptidase activity  
    enables serine-type peptidase activity PubMed 
    enables serine-type peptidase activity  
    enables ubiquitin ligase inhibitor activity  
    Items 1 - 25 of 32
    Process Evidence Code Pubs
    acts_upstream_of_or_within adult locomotory behavior  
    acts_upstream_of_or_within adult walking behavior  
    involved_in cellular response to growth factor stimulus  
    involved_in cellular response to heat  
    involved_in cellular response to interferon-beta  
    involved_in cellular response to oxidative stress  
    involved_in cellular response to retinoic acid  
    involved_in ceramide metabolic process PubMed 
    acts_upstream_of_or_within forebrain development  
    involved_in intracellular signal transduction  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage  
    acts_upstream_of_or_within mitochondrion organization  
    involved_in mitochondrion organization  
    involved_in negative regulation of type 2 mitophagy  
    involved_in neuron apoptotic process PubMed 
    acts_upstream_of_or_within neuron development  
    involved_in pentacyclic triterpenoid metabolic process PubMed 
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of cysteine-type endopeptidase activity  
    involved_in positive regulation of execution phase of apoptosis  
    involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  
    involved_in positive regulation of protein targeting to mitochondrion PubMed 
    involved_in programmed cell death  
    involved_in programmed cell death  
    involved_in protein catabolic process  
    involved_in proteolysis  
    involved_in proteolysis  
    acts_upstream_of_or_within regulation of multicellular organism growth  
    involved_in response to herbicide PubMed 
    Items 1 - 25 of 32
    Component Evidence Code Pubs
    part_of CD40 receptor complex  
    located_in chromatin  
    located_in cytoplasmic side of plasma membrane  
    located_in cytoskeleton  
    located_in cytosol  
    located_in membrane  
    located_in mitochondrial intermembrane space  
    is_active_in mitochondrion  
    located_in mitochondrion  
    located_in nucleus  
    part_of serine-type endopeptidase complex  

    General protein information

    Preferred Names
    serine protease HTRA2, mitochondrial
    Names
    high temperature requirement protein A2
    protease, serine, 25
    NP_001100069.1
    XP_063141858.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106599.2NP_001100069.1  serine protease HTRA2, mitochondrial

      See identical proteins and their annotated locations for NP_001100069.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158760
      UniProtKB/TrEMBL
      A0A8I6AYW8, B0BNB9, F7FLZ6
      Related
      ENSRNOP00000030076.4, ENSRNOT00000037333.7
      Conserved Domains (1) summary
      TIGR02037
      Location:150453
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      117114631..117117793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285788.1XP_063141858.1  serine protease HTRA2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A6IAJ2

    RNA

    1. XR_005503189.2 RNA Sequence

    2. XR_010065625.1 RNA Sequence

      Related
      ENSRNOT00000112194.2
    3. XR_010065626.1 RNA Sequence

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