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    Gipc1 GIPC PDZ domain containing family, member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83823, updated on 27-Dec-2024

    Summary

    Official Symbol
    Gipc1provided by RGD
    Official Full Name
    GIPC PDZ domain containing family, member 1provided by RGD
    Primary source
    RGD:68338
    See related
    EnsemblRapid:ENSRNOG00000003864 AllianceGenome:RGD:68338
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gipc; Rgs19; Rgs19ip1
    Summary
    Enables PDZ domain binding activity. Predicted to be involved in several processes, including negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of melanin biosynthetic process; and positive regulation of transforming growth factor beta receptor signaling pathway. Predicted to act upstream of or within several processes, including cellular response to interleukin-7; endothelial cell migration; and glutamate secretion. Located in brush border and endocytic vesicle. Is active in Schaffer collateral - CA1 synapse; postsynapse; and presynapse. Human ortholog(s) of this gene implicated in oculopharyngodistal myopathy 2. Orthologous to human GIPC1 (GIPC PDZ domain containing family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 90.1), Adrenal (RPKM 73.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Gipc1 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (41380125..41392078, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (24474291..24487083, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (24786604..24798231)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098561 Neighboring gene protein kinase N1 Neighboring gene prostaglandin E receptor 1 Neighboring gene cytochrome c-like Neighboring gene ribosomal protein S10, pseudogene 10 Neighboring gene DnaJ heat shock protein family (Hsp40) member B1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables PDZ domain binding PubMed 
    enables actin binding  
    enables actin binding  
    enables identical protein binding  
    enables identical protein binding  
    enables myosin binding  
    enables myosin binding  
    enables protein binding PubMed 
    enables signaling receptor binding  
    enables signaling receptor binding  
    Process Evidence Code Pubs
    involved_in cellular response to interleukin-7  
    acts_upstream_of_or_within cellular response to interleukin-7  
    involved_in chemical synaptic transmission  
    acts_upstream_of_or_within chemical synaptic transmission  
    involved_in endothelial cell migration  
    acts_upstream_of_or_within endothelial cell migration  
    involved_in glutamate secretion  
    acts_upstream_of_or_within glutamate secretion  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of cytokinesis  
    involved_in positive regulation of cytokinesis  
    involved_in positive regulation of melanin biosynthetic process  
    involved_in positive regulation of melanin biosynthetic process  
    involved_in positive regulation of melanin biosynthetic process  
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway  
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway  
    involved_in presynaptic modulation of chemical synaptic transmission  
    involved_in presynaptic modulation of chemical synaptic transmission  
    involved_in protein targeting  
    acts_upstream_of_or_within protein targeting  
    involved_in regulation of protein stability  
    involved_in regulation of protein stability  
    involved_in regulation of synaptic plasticity  
    acts_upstream_of_or_within regulation of synaptic plasticity  
    Items 1 - 20 of 25
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    located_in Schaffer collateral - CA1 synapse  
    is_active_in Schaffer collateral - CA1 synapse  
    located_in brush border PubMed 
    located_in cell cortex  
    located_in cell cortex  
    located_in cytoplasm  
    located_in cytoplasmic vesicle  
    located_in cytosol  
    located_in cytosol  
    located_in dendritic shaft  
    located_in dendritic shaft  
    located_in dendritic spine  
    located_in dendritic spine  
    located_in endocytic vesicle PubMed 
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    located_in membrane  
    located_in membrane  
    is_active_in postsynapse PubMed 
    is_active_in presynapse PubMed 
    located_in synaptic vesicle  
    located_in synaptic vesicle  
    located_in vesicle membrane  
    located_in vesicle membrane  
    Items 1 - 20 of 25

    General protein information

    Preferred Names
    PDZ domain-containing protein GIPC1
    Names
    GAIP C-terminus-interacting protein
    GLUT1 C-terminal-binding protein
    GLUT1CBP
    RGS-GAIP interacting protein, C-terminus
    RGS-GAIP-interacting protein
    RGS19-interacting protein 1
    regulator of G-protein signaling 19 interacting protein 1
    synectin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053341.3NP_445793.1  PDZ domain-containing protein GIPC1

      See identical proteins and their annotated locations for NP_445793.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      Q6GR70, Q9QUQ4, Q9Z254
      UniProtKB/TrEMBL
      A6IYD6
      Related
      ENSRNOP00000089319.2, ENSRNOT00000105318.2
      Conserved Domains (2) summary
      cd00992
      Location:132211
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd21180
      Location:261325
      GH2_GIPC; GIPC-homology 2 (GH2) domain found in the GIPC family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      41380125..41392078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098035.2XP_038953963.1  PDZ domain-containing protein GIPC1 isoform X1

      UniProtKB/Swiss-Prot
      Q6GR70, Q9QUQ4, Q9Z254
      UniProtKB/TrEMBL
      A6IYD6
      Related
      ENSRNOP00000005374.3, ENSRNOT00000005374.7
      Conserved Domains (2) summary
      cd00992
      Location:132211
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd21180
      Location:261325
      GH2_GIPC; GIPC-homology 2 (GH2) domain found in the GIPC family
    2. XM_017601372.3XP_017456861.1  PDZ domain-containing protein GIPC1 isoform X1

      UniProtKB/Swiss-Prot
      Q6GR70, Q9QUQ4, Q9Z254
      UniProtKB/TrEMBL
      A6IYD6
      Conserved Domains (2) summary
      cd00992
      Location:132211
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd21180
      Location:261325
      GH2_GIPC; GIPC-homology 2 (GH2) domain found in the GIPC family
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