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    Cdc42bpa CDC42 binding protein kinase alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114116, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cdc42bpaprovided by RGD
    Official Full Name
    CDC42 binding protein kinase alphaprovided by RGD
    Primary source
    RGD:621406
    See related
    EnsemblRapid:ENSRNOG00000002841 AllianceGenome:RGD:621406
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mrck; Pk428
    Summary
    Enables several functions, including ATP binding activity; identical protein binding activity; and magnesium ion binding activity. Involved in several processes, including actomyosin structure organization; protein phosphorylation; and regulation of small GTPase mediated signal transduction. Located in actomyosin; cell leading edge; and cell-cell junction. Orthologous to human CDC42BPA (CDC42 binding protein kinase alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 292.6), Lung (RPKM 199.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Cdc42bpa in Genome Data Viewer
    Location:
    13q26
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (94215359..94435681)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (91683775..91903732)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (98231326..98447762)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 28 Neighboring gene AT hook containing transcription factor 1 Neighboring gene uncharacterized LOC134481630 Neighboring gene coenzyme Q8A Neighboring gene presenilin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 34
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding PubMed 
    enables ATP binding  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables identical protein binding PubMed 
    enables identical protein binding  
    enables magnesium ion binding PubMed 
    enables magnesium ion binding  
    enables metal ion binding  
    enables protein binding PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 34
    Component Evidence Code Pubs
    is_active_in actomyosin  
    located_in actomyosin PubMed 
    located_in actomyosin  
    located_in cell leading edge PubMed 
    located_in cell-cell junction PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  
    is_active_in cytoskeleton  
    located_in lamellipodium  
    located_in lamellipodium  
    located_in lamellipodium  

    General protein information

    Preferred Names
    serine/threonine-protein kinase MRCK alpha
    Names
    MRCK alpha
    Ser-Thr protein kinase related to the myotonic dystrophy protein kinase
    myotonic dystrophy kinase-related CDC42-binding kinase alpha
    myotonic dystrophy protein kinase-like alpha
    mytonic dystrophy kinase-related Cdc42-binding kinase
    NP_446109.2
    XP_038946163.1
    XP_038946165.1
    XP_038946170.1
    XP_038946173.1
    XP_038946174.1
    XP_038946175.1
    XP_038946179.1
    XP_038946184.1
    XP_038946185.1
    XP_038946187.1
    XP_038946189.1
    XP_038946190.1
    XP_038946192.1
    XP_038946194.1
    XP_063128026.1
    XP_063128027.1
    XP_063128028.1
    XP_063128029.1
    XP_063128030.1
    XP_063128031.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053657.2NP_446109.2  serine/threonine-protein kinase MRCK alpha

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      O54874
      UniProtKB/TrEMBL
      A6JGG0, G3V6C9
      Related
      ENSRNOP00000003837.2, ENSRNOT00000003837.5
      Conserved Domains (6) summary
      COG0419
      Location:442969
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:10721206
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:12321496
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:10111070
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      94215359..94435681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090235.2XP_038946163.1  serine/threonine-protein kinase MRCK alpha isoform X1

      UniProtKB/Swiss-Prot
      O54874
      Conserved Domains (6) summary
      COG0419
      Location:442958
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:11231257
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:12831547
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:10621121
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    2. XM_039090251.2XP_038946179.1  serine/threonine-protein kinase MRCK alpha isoform X8

      UniProtKB/Swiss-Prot
      O54874
      Related
      ENSRNOP00000099199.1, ENSRNOT00000151561.1
      Conserved Domains (6) summary
      COG0419
      Location:442958
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:10591193
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:12191483
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:9981057
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    3. XM_039090262.2XP_038946190.1  serine/threonine-protein kinase MRCK alpha isoform X16

      UniProtKB/TrEMBL
      A0A8I6G3L7
      Conserved Domains (6) summary
      pfam08826
      Location:800860
      DMPK_coil; DMPK coiled coil domain like
      COG0419
      Location:442860
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:9781112
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:11381402
      CNH; CNH domain
      cl00040
      Location:917976
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    4. XM_063271959.1XP_063128029.1  serine/threonine-protein kinase MRCK alpha isoform X14

      UniProtKB/TrEMBL
      A0A8I6G3L7
    5. XM_063271956.1XP_063128026.1  serine/threonine-protein kinase MRCK alpha isoform X7

      UniProtKB/Swiss-Prot
      O54874
    6. XM_039090242.2XP_038946170.1  serine/threonine-protein kinase MRCK alpha isoform X3

      UniProtKB/Swiss-Prot
      O54874
      Conserved Domains (6) summary
      COG0419
      Location:442958
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:10881222
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:12481512
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:10271086
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    7. XM_039090257.2XP_038946185.1  serine/threonine-protein kinase MRCK alpha isoform X11

      UniProtKB/Swiss-Prot
      O54874
      UniProtKB/TrEMBL
      A0A8I6AWL9
      Related
      ENSRNOP00000093143.1, ENSRNOT00000102712.2
      Conserved Domains (6) summary
      COG0419
      Location:442958
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:10881222
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:12481512
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:10271086
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    8. XM_039090245.2XP_038946173.1  serine/threonine-protein kinase MRCK alpha isoform X4

      UniProtKB/Swiss-Prot
      O54874
      Conserved Domains (6) summary
      COG0419
      Location:442958
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:10751209
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:12351499
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:10141073
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    9. XM_039090259.2XP_038946187.1  serine/threonine-protein kinase MRCK alpha isoform X13

      UniProtKB/Swiss-Prot
      O54874
      Related
      ENSRNOP00000077481.2, ENSRNOT00000116713.2
      Conserved Domains (6) summary
      COG0419
      Location:442958
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:10751209
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:12351499
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:10141073
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    10. XM_039090237.2XP_038946165.1  serine/threonine-protein kinase MRCK alpha isoform X2

      UniProtKB/Swiss-Prot
      O54874
      Conserved Domains (6) summary
      COG0419
      Location:442969
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:11071241
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:12671531
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:10461105
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    11. XM_039090247.2XP_038946175.1  serine/threonine-protein kinase MRCK alpha isoform X6

      UniProtKB/Swiss-Prot
      O54874
      Conserved Domains (6) summary
      COG0419
      Location:442969
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:10721206
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:12321496
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:10111070
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    12. XM_039090261.2XP_038946189.1  serine/threonine-protein kinase MRCK alpha isoform X15

      UniProtKB/Swiss-Prot
      O54874
      UniProtKB/TrEMBL
      A0A8I5Y183
      Related
      ENSRNOP00000086891.1, ENSRNOT00000109203.2
      Conserved Domains (6) summary
      COG0419
      Location:442958
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:10591193
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:12191483
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:9981057
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    13. XM_039090246.2XP_038946174.1  serine/threonine-protein kinase MRCK alpha isoform X5

      UniProtKB/Swiss-Prot
      O54874
      Conserved Domains (6) summary
      COG0419
      Location:442944
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:10741208
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:12341498
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:10131072
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    14. XM_039090256.2XP_038946184.1  serine/threonine-protein kinase MRCK alpha isoform X10

      UniProtKB/TrEMBL
      A0A8I6A4M2
      Conserved Domains (6) summary
      COG0419
      Location:442949
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:10391173
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:11991463
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:9781037
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    15. XM_039090264.2XP_038946192.1  serine/threonine-protein kinase MRCK alpha isoform X17

      UniProtKB/TrEMBL
      A0A8I6A4M2
      Related
      ENSRNOP00000103002.1, ENSRNOT00000151394.1
      Conserved Domains (6) summary
      COG0419
      Location:442949
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:10391173
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:11991463
      CNH; CNH domain
      pfam15796
      Location:530608
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl00040
      Location:9781037
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    16. XM_063271957.1XP_063128027.1  serine/threonine-protein kinase MRCK alpha isoform X9

      UniProtKB/TrEMBL
      A0A8I6G3L7
    17. XM_039090266.2XP_038946194.1  serine/threonine-protein kinase MRCK alpha isoform X20

      UniProtKB/TrEMBL
      A0A8I5ZRP1, A0A8I6G3L7
      Related
      ENSRNOP00000081450.2, ENSRNOT00000105577.2
      Conserved Domains (6) summary
      pfam08826
      Location:800860
      DMPK_coil; DMPK coiled coil domain like
      COG0419
      Location:442860
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd01243
      Location:9781112
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05623
      Location:4412
      STKc_MRCK_alpha; Catalytic domain of the Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) alpha
      pfam00780
      Location:11381402
      CNH; CNH domain
      cl00040
      Location:917976
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    18. XM_063271960.1XP_063128030.1  serine/threonine-protein kinase MRCK alpha isoform X18

      UniProtKB/TrEMBL
      A0A8I6G3L7
    19. XM_063271961.1XP_063128031.1  serine/threonine-protein kinase MRCK alpha isoform X19

      UniProtKB/TrEMBL
      A6JGG1
    20. XM_063271958.1XP_063128028.1  serine/threonine-protein kinase MRCK alpha isoform X12

      UniProtKB/TrEMBL
      A0A0G2K5Z1
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