Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gabra4provided by RGD
Official Full Name: gamma-aminobutyric acid type A receptor subunit alpha 4provided by RGD
Primary source: RGD:621670
See related: EnsemblRapid:ENSRNOG00000002336 AllianceGenome:RGD:621670
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in several processes, including GABAergic synaptic transmission; chloride transmembrane transport; and inhibitory synapse assembly. Predicted to act upstream of or within central nervous system development. Is active in GABA-ergic synapse and postsynaptic specialization membrane. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human GABRA4 (gamma-aminobutyric acid type A receptor subunit alpha4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 218.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 14p11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (36944747..37021652)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (36590782..36667724)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (39154072..39230994)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that alpha4betadelta-GABAA receptors in dorsal hippocampal CA1 of adolescent female rats traffic to the plasma membrane of dendritic spines following voluntary exercise and contribute to protection of animals from activity-based anorexia through localization at excitatory synapses.
Title: α4βδ-GABA(A) receptors in dorsal hippocampal CA1 of adolescent female rats traffic to the plasma membrane of dendritic spines following voluntary exercise and contribute to protection of animals from activity-based anorexia through localization at excitatory synapses.
the subunit arrangement of alpha4beta2delta GABAA receptors is not strongly predefined but is mostly satisfying the 2:2:1 subunit stoichiometry for alpha4, beta2, and delta subunits and that several subunit arrangements result in receptors with similar functional properties tuned to physiological conditions.
Title: Toward Understanding Functional Properties and Subunit Arrangement of α4β2δ γ-Aminobutyric Acid, Type A (GABAA) Receptors.
spontaneous, recurrent seizures that define chronic epilepsy may influence changes in GABAA receptor alpha4 expression
Title: Effect of spontaneous seizures on GABAA receptor α4 subunit expression in an animal model of temporal lobe epilepsy.
The expression of Gabra4 in neonatal hippocampus was chaged in response to alterations in neurosteroid levels.
Title: Neonatal finasteride administration alters hippocampal α4 and δ GABAAR subunits expression and behavioural responses to progesterone in adult rats.
alpha4betadelta GABA receptors play a role in mood and cognition at puberty in female mice.
Title: The influence of stress at puberty on mood and learning: role of the α4βδ GABAA receptor.
Adolescent female rats exhibiting activity-based anorexia express elevated levels of GABAA receptor alpha4 subunit at the plasma membrane of hippocampal CA1 spines
Title: Adolescent female rats exhibiting activity-based anorexia express elevated levels of GABA(A) receptor α4 and δ subunits at the plasma membrane of hippocampal CA1 spines.
These data demonstrate that altered expressions of GABA(A)R (alpha4, gamma2) and KCC2 and astrogliosis observed in TRMs hippocampus may provide us good therapeutic targets for the treatment of genetic epilepsy.
Title: Altered expression of GABAA receptors (α4, γ2 subunit), potassium chloride cotransporter 2 and astrogliosis in tremor rat hippocampus.
No change in alpha 4 subunit expression was seen in hippocampi of controlled cortical impact and post-traumatic epilepsy groups.
Title: Alterations of GABA(A) and glutamate receptor subunits and heat shock protein in rat hippocampus following traumatic brain injury and in posttraumatic epilepsy.
Ethanol-induced increases in GABA(A) receptor alpha4 subunit expression in cerebral cortical neurons appear to be selectively mediated by protein kinase C (PKC)gamma and not PKCbeta.
Title: PKCγ is required for ethanol-induced increases in GABA(A) receptor α4 subunit expression in cultured cerebral cortical neurons.
Alpha4-containing GABAA receptors in the nucleus accumbens mediate moderate intake of alcohol.
Title: Alpha4-containing GABAA receptors in the nucleus accumbens mediate moderate intake of alcohol.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gabra4 (e-PCR), detects polymorphism
- UniSTS:525650

D5Buc33 (e-PCR), detects polymorphism
- UniSTS:142525

Gabra4 (e-PCR), detects polymorphism
- UniSTS:265417

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to GABA-A receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables GABA-A receptor activity	TAS Traceable Author Statement more info	PubMed
enables GABA-gated chloride ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to benzodiazepine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	EXP Inferred from Experiment more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within central nervous system development	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in gamma-aminobutyric acid signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in inhibitory synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, GABAergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of GABA-A receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GABA-A receptor complex	ISO Inferred from Sequence Orthology more info
part_of GABA-A receptor complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in GABA-ergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
is_active_in dendrite membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: gamma-aminobutyric acid receptor subunit alpha-4

Names: GABA(A) receptor subunit alpha-4; GABA-A receptor alpha-4 subunit; GABAAR subunit alpha-4; gamma-aminobutyric acid (GABA) A receptor, alpha 4; gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 4; gamma-aminobutyric acid type A receptor alpha4 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080587.3 → NP_542154.3 gamma-aminobutyric acid receptor subunit alpha-4 precursor

See identical proteins and their annotated locations for NP_542154.3

Status: PROVISIONAL

Source sequence(s)

S55933

UniProtKB/Swiss-Prot

P28471

UniProtKB/TrEMBL

A6JD83

Related

ENSRNOP00000003191.5, ENSRNOT00000003191.8

Conserved Domains (3) summary

TIGR00860
Location:13 → 539

LIC; Cation transporter family protein

pfam02931
Location:49 → 256

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:263 → 536

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

36944747..37021652

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091568.2 → XP_038947496.1 gamma-aminobutyric acid receptor subunit alpha-4 isoform X1

Conserved Domains (2) summary

cd19037
Location:57 → 255

LGIC_ECD_GABAAR_A4; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-4 (GABAAR-A4 or GABRA4)

cl38911
Location:258 → 291

LGIC_TM; transmembrane domain of Cys-loop neurotransmitter-gated ion channels
XM_039091570.2 → XP_038947498.1 gamma-aminobutyric acid receptor subunit alpha-4 isoform X3

Conserved Domains (2) summary

cd19037
Location:57 → 255

LGIC_ECD_GABAAR_A4; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-4 (GABAAR-A4 or GABRA4)

cl38911
Location:258 → 294

LGIC_TM; transmembrane domain of Cys-loop neurotransmitter-gated ion channels
XM_039091569.2 → XP_038947497.1 gamma-aminobutyric acid receptor subunit alpha-4 isoform X2

Conserved Domains (3) summary

cd19037
Location:57 → 255

LGIC_ECD_GABAAR_A4; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-4 (GABAAR-A4 or GABRA4)

cd03559
Location:258 → 281

LGIC_TM; TM1 helix [structural motif]

cl38911
Location:258 → 291

LGIC_TM; transmembrane domain of Cys-loop neurotransmitter-gated ion channels