Cldn7 claudin 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cldn7provided by RGD
Official Full Name: claudin 7provided by RGD
Primary source: RGD:68432
See related: EnsemblRapid:ENSRNOG00000017325 AllianceGenome:RGD:68432
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: cld-7
Summary: Enables cell adhesion molecule binding activity and protein domain specific binding activity. Involved in several processes, including negative regulation of protein-containing complex assembly; positive regulation of cell motility; and response to ethanol. Located in basolateral plasma membrane and lateral plasma membrane. Orthologous to human CLDN7 (claudin 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 92.5), Kidney (RPKM 59.8) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (55188670..55190871)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (54689684..54692177)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (56576326..56578632)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pancreatic adenocarcinoma cell line ASMLL-claudin7 (cld7) knockdown (kd) and ASML-cld7 mutated palmitoylation cells show reduced motility and invasiveness.
Title: Palmitoylated claudin7 captured in glycolipid-enriched membrane microdomains promotes metastasis via associated transmembrane and cytosolic molecules.
claudin 7 demonstrates a distinct basal and lateral localisation in the uterine luminal and glandular epithelium throughout early pregnancy
Title: Claudin 7 is reduced in uterine epithelial cells during early pregnancy in the rat.
cld7 supports tumorigenic features of EpC by provoking EpC cleavage and thereby its cotranscription factor activity
Title: EpCAM-associated claudin-7 supports lymphatic spread and drug resistance in rat pancreatic cancer.
Claudin-7 in lateral membranes may exist in a nonpolymerized form and may play some different roles other than the formation of tight junctions strands, for example, in the formation of a pool of claudin proteins or in the reinforcement of cell adhesion.
Title: Claudin-7 expressed on lateral membrane of rat epididymal epithelium does not form aberrant tight junction strands.
Claudin-7, kidney injury molecule-1 (Kim-1), and matrix metalloproteinase-7 (MMP-7) changed by aging and changes attenuated by caloric restriction.
Title: Increased susceptibility of aging kidney to ischemic injury: identification of candidate genes changed during aging, but corrected by caloric restriction.
Wnk4 phosphorylates ser(206) of Cldn7 and promotes paracellular Cl-ion permeability.
Title: WNK4 phosphorylates ser(206) of claudin-7 and promotes paracellular Cl(-) permeability.
An association between claudin-7 and EpCAM/Tacstd1 is noted in rat and human tumors and in non-transformed tissues of the gastrointestinal tract.
Title: The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7.
We identified novel cell surface markers specific for hepatic progenitor/oval cells. Six are unique for the adult progenitors (CD133, claudin-7, cadherin 22, mucin-1, ros-1, Gabrp).
Title: Novel hepatic progenitor cell surface markers in the adult rat liver.

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:465381 (e-PCR)
- UniSTS:465381

Cldn7 (e-PCR), detects polymorphism
- UniSTS:465381

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bicellular tight junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell motility	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in apicolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	ISS Inferred from Sequence or Structural Similarity more info
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: claudin-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.