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    Fhl1 four and a half LIM domains 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25177, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fhl1provided by RGD
    Official Full Name
    four and a half LIM domains 1provided by RGD
    Primary source
    RGD:2615
    See related
    EnsemblRapid:ENSRNOG00000000875 AllianceGenome:RGD:2615
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SLIM1
    Summary
    Predicted to enable transmembrane transporter binding activity. Predicted to be involved in several processes, including negative regulation of mitotic cell cycle phase transition; regulation of membrane depolarization; and regulation of potassium ion transport. Predicted to be located in cytosol; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in Uruguay faciocardiomusculoskeletal syndrome; X-linked Emery-Dreifuss muscular dystrophy 6; reducing body myopathy 1A; and reducing body myopathy 1B. Orthologous to human FHL1 (four and a half LIM domains 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 6067.5), Lung (RPKM 1888.6) and 2 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Fhl1 in Genome Data Viewer
    Location:
    Xq36
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (139592794..139652290)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (134555399..134614930)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (159112516..159172528)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 9 member A6 Neighboring gene basic transcription factor 3, pseudogene 4 Neighboring gene U6 spliceosomal RNA Neighboring gene MAP7 domain containing 3 Neighboring gene adhesion G protein-coupled receptor G4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding  
    enables transmembrane transporter binding  
    enables transmembrane transporter binding  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytosol  
    located_in nucleus  
    located_in plasma membrane  

    General protein information

    Preferred Names
    four and a half LIM domains protein 1
    Names
    FHL-1
    skeletal muscle LIM-protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033926.2NP_001029098.1  four and a half LIM domains protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001029098.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC061782, CK840296, FQ119120
      UniProtKB/TrEMBL
      A0A8I6A745, Q6P792
      Related
      ENSRNOP00000001169.6, ENSRNOT00000001169.8
      Conserved Domains (5) summary
      cd09344
      Location:56109
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09348
      Location:233296
      LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09424
      Location:117174
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:178230
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:2149
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    2. NM_001271199.1NP_001258128.1  four and a half LIM domains protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001258128.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains 2 alternate exons at the 5' end compared to variant 1, which results in translation initiation from an in-frame downstream AUG and an isoform (3) with a shorter N-terminus compared to isoform 1. Variants 3 and 4 encode the same isoform.
      Source sequence(s)
      AF134773, BC061782, CK840296, JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q9WUH4
      UniProtKB/TrEMBL
      A0A8I6A745, A6KSP3
      Related
      ENSRNOP00000074052.1, ENSRNOT00000084594.3
      Conserved Domains (5) summary
      cd09344
      Location:4093
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09348
      Location:217280
      LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09424
      Location:101158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:162214
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:533
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    3. NM_001271200.1NP_001258129.1  four and a half LIM domains protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001258129.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon at the 5' end compared to variant 1, which results in translation initiation from an in-frame downstream AUG and an isoform (3) with a shorter N-terminus compared to isoform 1. Variants 3 and 4 encode the same isoform.
      Source sequence(s)
      BC061782, CK477468, CK840296, FM042472
      UniProtKB/Swiss-Prot
      Q9WUH4
      UniProtKB/TrEMBL
      A0A8I6A745, A6KSP3
      Related
      ENSRNOP00000088085.2, ENSRNOT00000110431.2
      Conserved Domains (5) summary
      cd09344
      Location:4093
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09348
      Location:217280
      LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09424
      Location:101158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:162214
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:533
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    4. NM_001271201.1NP_001258130.1  four and a half LIM domains protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001258130.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains an alternate exon at the 5' end and lacks an exon in the 3' coding region compared to variant 1, which results in an isoform (4) with a shorter N-terminus and a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC061782, CK840296, FM042472
      UniProtKB/TrEMBL
      A6KSP7
      Related
      ENSRNOP00000100750.1, ENSRNOT00000170371.1
      Conserved Domains (3) summary
      cd09344
      Location:4093
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09424
      Location:101158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:533
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    5. NM_145669.3NP_663702.1  four and a half LIM domains protein 1 isoform 2

      See identical proteins and their annotated locations for NP_663702.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region compared to variant 1, which results in a frame-shift and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AY115564, BC061782, CK840296, FQ119120
      UniProtKB/TrEMBL
      F8WFH4, Q8K3G3
      Conserved Domains (3) summary
      cd09344
      Location:56109
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09424
      Location:117174
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:2149
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      139592794..139652290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257672.5XP_006257734.1  four and a half LIM domains protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006257734.1

      UniProtKB/TrEMBL
      A0A8L2R9G0, A6KSP6
      Related
      ENSRNOP00000049677.5, ENSRNOT00000043820.7
      Conserved Domains (4) summary
      cd09344
      Location:4093
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09424
      Location:101158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:162214
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:533
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    2. XM_006257676.5XP_006257738.1  four and a half LIM domains protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006257738.1

      UniProtKB/TrEMBL
      A0A8L2R9G0, A6KSP6
      Related
      ENSRNOP00000074817.2, ENSRNOT00000087274.3
      Conserved Domains (4) summary
      cd09344
      Location:4093
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09424
      Location:101158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:162214
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:533
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    3. XM_006257674.5XP_006257736.1  four and a half LIM domains protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006257736.1

      UniProtKB/TrEMBL
      A0A8L2R9G0, A6KSP6
      Conserved Domains (4) summary
      cd09344
      Location:4093
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09424
      Location:101158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:162214
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:533
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    4. XM_006257673.4XP_006257735.1  four and a half LIM domains protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006257735.1

      UniProtKB/TrEMBL
      A0A8L2R9G0, A6KSP6
      Conserved Domains (4) summary
      cd09344
      Location:4093
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09424
      Location:101158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:162214
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:533
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    5. XM_006257671.5XP_006257733.1  four and a half LIM domains protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K338, A0A8L2R9G0
      Related
      ENSRNOP00000072490.1, ENSRNOT00000083502.3
      Conserved Domains (4) summary
      cd09344
      Location:56109
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09424
      Location:117174
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:178230
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:2149
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    6. XM_006257675.5XP_006257737.1  four and a half LIM domains protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006257737.1

      UniProtKB/TrEMBL
      A0A8L2R9G0, A6KSP6
      Conserved Domains (4) summary
      cd09344
      Location:4093
      LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
      cd09424
      Location:101158
      LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cd09429
      Location:162214
      LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
      cl02475
      Location:533
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
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