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    Nudt5 nudix hydrolase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361274, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nudt5provided by RGD
    Official Full Name
    nudix hydrolase 5provided by RGD
    Primary source
    RGD:1359284
    See related
    EnsemblRapid:ENSRNOG00000017741 AllianceGenome:RGD:1359284
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including magnesium ion binding activity; protein homodimerization activity; and pyrophosphatase activity. Predicted to be involved in D-ribose catabolic process; chromatin remodeling; and nucleoside phosphate metabolic process. Predicted to act upstream of or within nucleobase-containing compound metabolic process. Predicted to be active in nucleus. Orthologous to human NUDT5 (nudix hydrolase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 146.6), Kidney (RPKM 123.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nudt5 in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (77345041..77368308, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (72435690..72459008, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (76387027..76410309, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene dehydrogenase E1 and transketolase domain containing 1 Neighboring gene cytochrome c oxidase subunit VIb polypeptide 1-like Neighboring gene large ribosomal subunit protein eL37-like Neighboring gene SEC61 translocon subunit alpha 2 Neighboring gene cell division cycle 123 Neighboring gene uncharacterized LOC102551026

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC94209

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity  
    NOT enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity  
    enables 8-oxo-GDP phosphatase activity  
    enables 8-oxo-dGDP phosphatase activity  
    enables 8-oxo-dGDP phosphatase activity  
    enables ADP-ribose diphosphatase activity  
    enables ADP-ribose diphosphatase activity  
    enables ADP-ribose diphosphatase activity  
    enables ADP-sugar diphosphatase activity  
    enables ADP-sugar diphosphatase activity  
    enables identical protein binding  
    enables magnesium ion binding  
    enables magnesium ion binding  
    enables nucleoside diphosphate phosphatase activity  
    enables nucleotidyltransferase activity  
    enables nucleotidyltransferase activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables pyrophosphatase activity  
    enables snoRNA binding  
    enables snoRNA binding  
    Process Evidence Code Pubs
    involved_in ATP generation from poly-ADP-D-ribose  
    involved_in D-ribose catabolic process  
    involved_in D-ribose catabolic process  
    involved_in chromatin remodeling  
    involved_in chromatin remodeling  
    acts_upstream_of_or_within nucleobase-containing compound metabolic process  
    involved_in nucleoside phosphate metabolic process  
    involved_in ribonucleoside diphosphate catabolic process  
    involved_in ribonucleoside diphosphate catabolic process  
    involved_in ribose phosphate metabolic process  
    Component Evidence Code Pubs
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    ADP-sugar pyrophosphatase
    Names
    8-oxo-dGDP phosphatase
    nuclear ATP-synthesis protein NUDIX5
    nucleoside diphosphate-linked moiety X motif 5
    nudix (nucleoside diphosphate linked moiety X)-type motif 5
    nudix motif 5
    nudix-type motif 5
    NP_001007734.1
    XP_008770097.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007733.1NP_001007734.1  ADP-sugar pyrophosphatase

      See identical proteins and their annotated locations for NP_001007734.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079176
      UniProtKB/Swiss-Prot
      Q6AY63
      UniProtKB/TrEMBL
      A0A140TAD1
      Related
      ENSRNOP00000075734.1, ENSRNOT00000082669.3
      Conserved Domains (1) summary
      cd03424
      Location:60207
      ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      77345041..77368308 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008771875.4XP_008770097.1  ADP-sugar pyrophosphatase isoform X1

      UniProtKB/TrEMBL
      A0A140TAD1
      Conserved Domains (1) summary
      cd03424
      Location:60204
      ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...
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