Them5 thioesterase superfamily member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Them5provided by RGD
Official Full Name: thioesterase superfamily member 5provided by RGD
Primary source: RGD:1562059
See related: EnsemblRapid:ENSRNOG00000043445 AllianceGenome:RGD:1562059
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: C2cd4d; RGD1562059
Summary: Predicted to enable long-chain fatty acyl-CoA hydrolase activity. Predicted to be involved in cardiolipin acyl-chain remodeling and long-chain fatty-acyl-CoA metabolic process. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Orthologous to human THEM5 (thioesterase superfamily member 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Uterus (RPKM 84.0), Testes (RPKM 65.6) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (184665335..184675041)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (181980783..181986002)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (195582781..195588000)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables long-chain fatty acyl-CoA hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cardiolipin acyl-chain remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiolipin acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in long-chain fatty-acyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty-acyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: acyl-coenzyme A thioesterase THEM5

Names: C2 calcium-dependent domain containing 4D; C2 calcium-dependent domain-containing protein 4D

NP_001102028.1

EC 3.1.2.2

XP_063138240.1

EC 3.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108558.1 → NP_001102028.1 acyl-coenzyme A thioesterase THEM5

See identical proteins and their annotated locations for NP_001102028.1

Status: PROVISIONAL

Source sequence(s)

CH474015

UniProtKB/TrEMBL

A6K2Q0, A6K2Q1, D3ZHF1

Related

ENSRNOP00000060470.3, ENSRNOT00000066020.4

Conserved Domains (1) summary

cl00509
Location:132 → 237

hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...