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    Micu1 mitochondrial calcium uptake 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365567, updated on 4-Jan-2025

    Summary

    Symbol
    Micu1provided by RGD
    Full Name
    mitochondrial calcium uptake 1provided by RGD
    Primary source
    RGD:735033
    See related
    EnsemblRapid:ENSRNOG00000043436 AllianceGenome:RGD:735033
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cbara1
    Summary
    Predicted to enable several functions, including calcium channel inhibitor activity; calcium ion sensor activity; and protein heterodimerization activity. Predicted to be involved in several processes, including calcium ion transport; cellular response to calcium ion starvation; and positive regulation of cristae formation. Predicted to be located in mitochondrial crista junction and mitochondrial intermembrane space. Predicted to be part of uniplex complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in myopathy with extrapyramidal signs. Orthologous to human MICU1 (mitochondrial calcium uptake 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Brain (RPKM 228.9), Lung (RPKM 175.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Micu1 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (28211774..28357928)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (27668681..27816322)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (29284833..29433617)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene fatty acid binding protein 5, pseudogene 3 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene DnaJ heat shock protein family (Hsp40) member B12 Neighboring gene uncharacterized LOC120098848

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium channel inhibitor activity  
    enables calcium channel inhibitor activity  
    enables calcium channel regulator activity  
    enables calcium ion binding  
    enables calcium ion binding  
    enables calcium ion binding  
    enables calcium ion binding  
    enables calcium ion sensor activity  
    enables calcium ion sensor activity  
    enables calcium ion sensor activity  
    enables identical protein binding  
    enables identical protein binding  
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    Items 1 - 25 of 27
    Process Evidence Code Pubs
    involved_in calcium import into the mitochondrion  
    involved_in calcium import into the mitochondrion  
    involved_in calcium import into the mitochondrion  
    involved_in calcium import into the mitochondrion  
    involved_in calcium ion import  
    involved_in calcium ion import  
    involved_in calcium ion import  
    involved_in cellular response to calcium ion  
    involved_in cellular response to calcium ion  
    involved_in cellular response to calcium ion starvation  
    involved_in cellular response to calcium ion starvation  
    involved_in mitochondrial calcium ion homeostasis  
    involved_in mitochondrial calcium ion homeostasis  
    involved_in mitochondrial calcium ion homeostasis  
    involved_in mitochondrial calcium ion transmembrane transport  
    involved_in mitochondrial calcium ion transmembrane transport  
    involved_in positive regulation of cristae formation  
    involved_in positive regulation of cristae formation  
    involved_in positive regulation of cristae formation  
    involved_in positive regulation of mitochondrial calcium ion concentration  
    involved_in positive regulation of mitochondrial calcium ion concentration  
    involved_in positive regulation of mitochondrial calcium ion concentration  
    involved_in protein homooligomerization  
    involved_in protein homooligomerization  
    involved_in regulation of cellular hyperosmotic salinity response  
    involved_in regulation of cellular hyperosmotic salinity response  
    involved_in regulation of cellular hyperosmotic salinity response  
    Items 1 - 25 of 27
    Component Evidence Code Pubs
    part_of calcium channel complex  
    part_of calcium channel complex  
    located_in mitochondrial crista junction  
    located_in mitochondrial crista junction  
    located_in mitochondrial inner membrane  
    is_active_in mitochondrial inner membrane  
    located_in mitochondrial inner membrane  
    located_in mitochondrial inner membrane  
    located_in mitochondrial intermembrane space  
    located_in mitochondrial intermembrane space  
    located_in mitochondrial intermembrane space  
    located_in mitochondrial membrane  
    located_in mitochondrial membrane  
    is_active_in mitochondrion  
    located_in mitochondrion  
    part_of uniplex complex  
    part_of uniplex complex  
    part_of uniplex complex  
    part_of uniplex complex  

    General protein information

    Preferred Names
    calcium uptake protein 1, mitochondrial
    Names
    calcium binding atopy-related autoantigen 1
    calcium-binding atopy-related autoantigen 1 homolog
    calcium-binding atopy-related autoantigen 1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199412.2NP_955444.2  calcium uptake protein 1, mitochondrial

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      Q6P6Q9
      Related
      ENSRNOP00000060514.4, ENSRNOT00000067405.4
      Conserved Domains (1) summary
      cd16173
      Location:224443
      EFh_MICU1; EF-hand, calcium binding motif, found in calcium uptake protein 1, mitochondrial (MICU1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      28211774..28357928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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