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    Hoxb3 homeo box B3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303488, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hoxb3provided by RGD
    Official Full Name
    homeo box B3provided by RGD
    Primary source
    RGD:1310780
    See related
    EnsemblRapid:ENSRNOG00000008313 AllianceGenome:RGD:1310780
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including angiogenesis; embryonic skeletal system morphogenesis; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including hemopoiesis; nervous system development; and thyroid gland development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human HOXB3 (homeobox B3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 61.6), Adrenal (RPKM 46.7) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Hoxb3 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (81786001..81810655)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (81258739..81314134)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (84170629..84196823)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene microRNA 10a Neighboring gene homeo box B4 Neighboring gene uncharacterized LOC102550580 Neighboring gene homeobox B2 Neighboring gene homeo box B1

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in angiogenesis  
    involved_in anterior/posterior pattern specification  
    acts_upstream_of_or_within anterior/posterior pattern specification  
    acts_upstream_of_or_within cartilage development  
    acts_upstream_of_or_within definitive hemopoiesis  
    involved_in embryonic skeletal system morphogenesis  
    acts_upstream_of_or_within embryonic skeletal system morphogenesis  
    acts_upstream_of_or_within face development  
    acts_upstream_of_or_within glossopharyngeal nerve morphogenesis  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within regulation of neurogenesis  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within rhombomere development  
    acts_upstream_of_or_within thyroid gland development  
    Component Evidence Code Pubs
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107042.1 → NP_001100512.1  homeobox protein Hox-B3

      See identical proteins and their annotated locations for NP_001100512.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A6HIE8
      Conserved Domains (2) summary
      pfam00046
      Location:191 → 244
      Homeobox; Homeobox domain
      pfam13293
      Location:365 → 427
      DUF4074; Domain of unknown function (DUF4074)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      81786001..81810655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597314.3 → XP_017452803.1  homeobox protein Hox-B3 isoform X1

      UniProtKB/TrEMBL
      A6HIE8
      Conserved Domains (2) summary
      pfam00046
      Location:191 → 244
      Homeobox; Homeobox domain
      pfam13293
      Location:365 → 427
      DUF4074; Domain of unknown function (DUF4074)
    2. XM_017597315.3 → XP_017452804.1  homeobox protein Hox-B3 isoform X1

      UniProtKB/TrEMBL
      A6HIE8
      Conserved Domains (2) summary
      pfam00046
      Location:191 → 244
      Homeobox; Homeobox domain
      pfam13293
      Location:365 → 427
      DUF4074; Domain of unknown function (DUF4074)
    3. XM_006247194.5 → XP_006247256.1  homeobox protein Hox-B3 isoform X2

      See identical proteins and their annotated locations for XP_006247256.1

      UniProtKB/TrEMBL
      B2RYQ0, F7FL39
      Related
      ENSRNOP00000011027.5, ENSRNOT00000011027.8
      Conserved Domains (2) summary
      pfam00046
      Location:190 → 243
      Homeobox; Homeobox domain
      pfam13293
      Location:364 → 426
      DUF4074; Domain of unknown function (DUF4074)
    4. XM_039086074.2 → XP_038942002.1  homeobox protein Hox-B3 isoform X1

      UniProtKB/TrEMBL
      A6HIE8
      Conserved Domains (2) summary
      pfam00046
      Location:191 → 244
      Homeobox; Homeobox domain
      pfam13293
      Location:365 → 427
      DUF4074; Domain of unknown function (DUF4074)
    5. XM_039086075.2 → XP_038942003.1  homeobox protein Hox-B3 isoform X1

      UniProtKB/TrEMBL
      A6HIE8
      Conserved Domains (2) summary
      pfam00046
      Location:191 → 244
      Homeobox; Homeobox domain
      pfam13293
      Location:365 → 427
      DUF4074; Domain of unknown function (DUF4074)
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