Nexmif neurite extension and migration factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nexmifprovided by RGD
Official Full Name: neurite extension and migration factorprovided by RGD
Primary source: RGD:1561931
See related: EnsemblRapid:ENSRNOG00000021589 AllianceGenome:RGD:1561931
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Xpn; KIDLIA; KIAA2022; RGD1561931
Summary: Involved in negative regulation of cell adhesion and negative regulation of neuron migration. Predicted to be located in cytosol; midbody; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 98. Orthologous to human NEXMIF (neurite extension and migration factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 121.6), Brain (RPKM 67.2) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (73153786..73284943, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (69088076..69219253, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (74943440..75053559, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of KIAA2022/KIDLIA leads to altered neuron migration and a reduction in dendritic growth and disorganized apical dendrite projections in layer II/III cortical neurons. In cultured neurons loss of KIDLIA expression also leads to suppression of dendritic growth and branching. KIDLIA suppression leads to an increase in cell-surface N-cadherin and an elevated association of N-cadherin with delta-catenin.
Title: The X-Linked Autism Protein KIAA2022/KIDLIA Regulates Neurite Outgrowth via N-Cadherin and δ-Catenin Signaling.
Result showed that siRNA-mediated KIAA2022 knockdown resulted in marked impairment in neurite outgrowth including both the dendrites and the axons, suggesting a major role for KIAA2022 in neuron development and brain function.
Title: Loss of function of KIAA2022 causes mild to severe intellectual disability with an autism spectrum disorder and impairs neurite outgrowth.

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General gene information

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Markers

C77370 (e-PCR), detects polymorphism
- UniSTS:526851

RH36660 (e-PCR)
- UniSTS:85790

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in negative regulation of cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell adhesion mediated by integrin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell-cell adhesion mediated by cadherin	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell-cell adhesion mediated by cadherin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neurite extension and migration factor

Names: XLMR protein related to neurite extension

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313815.1 → NP_001300744.1 neurite extension and migration factor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

D3ZGX1

Related

ENSRNOP00000036176.6, ENSRNOT00000035653.9

Conserved Domains (1) summary

pfam15735
Location:291 → 691

DUF4683; Domain of unknown function (DUF4683)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

73153786..73284943 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099592.2 → XP_038955520.1 neurite extension and migration factor isoform X1

UniProtKB/Swiss-Prot

D3ZGX1

Conserved Domains (1) summary

pfam15735
Location:291 → 691

DUF4683; Domain of unknown function (DUF4683)
XM_039099590.2 → XP_038955518.1 neurite extension and migration factor isoform X1

UniProtKB/Swiss-Prot

D3ZGX1

Conserved Domains (1) summary

pfam15735
Location:291 → 691

DUF4683; Domain of unknown function (DUF4683)
XM_039099591.2 → XP_038955519.1 neurite extension and migration factor isoform X1

UniProtKB/Swiss-Prot

D3ZGX1

Conserved Domains (1) summary

pfam15735
Location:291 → 691

DUF4683; Domain of unknown function (DUF4683)