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    Spdl1 spindle apparatus coiled-coil protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303037, updated on 9-Dec-2024

    Summary

    Official Symbol
    Spdl1provided by RGD
    Official Full Name
    spindle apparatus coiled-coil protein 1provided by RGD
    Primary source
    RGD:1306908
    See related
    EnsemblRapid:ENSRNOG00000007292 AllianceGenome:RGD:1306908
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccdc99; RGD1306908
    Summary
    Predicted to enable enzyme binding activity and kinetochore binding activity. Predicted to be involved in several processes, including establishment of mitotic spindle orientation; mitotic metaphase chromosome alignment; and protein localization to kinetochore. Predicted to be located in nucleus. Predicted to be part of outer kinetochore. Predicted to be active in spindle pole. Orthologous to human SPDL1 (spindle apparatus coiled-coil protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 117.4), Testes (RPKM 61.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Spdl1 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (19773456..19798341, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (19269125..19294213, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (19628070..19652914, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene dedicator of cytokinesis 2 Neighboring gene uncharacterized LOC134480661 Neighboring gene uncharacterized LOC120095065 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC124977

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding  
    enables kinetochore binding  
    enables kinetochore binding  
    enables kinetochore binding  
    Process Evidence Code Pubs
    involved_in cell division  
    involved_in cell migration  
    involved_in cell migration  
    involved_in establishment of mitotic spindle orientation  
    involved_in establishment of mitotic spindle orientation  
    involved_in establishment of mitotic spindle orientation  
    involved_in mitotic metaphase chromosome alignment  
    involved_in mitotic metaphase chromosome alignment  
    involved_in mitotic metaphase chromosome alignment  
    involved_in mitotic spindle assembly checkpoint signaling  
    involved_in protein localization to kinetochore  
    involved_in protein localization to kinetochore  
    involved_in protein localization to kinetochore  
    Component Evidence Code Pubs
    located_in centrosome  
    located_in cytoplasm  
    located_in nucleus  
    located_in nucleus  
    part_of outer kinetochore  
    part_of outer kinetochore  
    part_of outer kinetochore  
    is_active_in spindle pole  
    located_in spindle pole  
    located_in spindle pole  

    General protein information

    Preferred Names
    protein Spindly
    Names
    coiled-coil domain containing 99
    coiled-coil domain-containing protein 99
    spindle apparatus coiled-coil domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034138.1NP_001029310.1  protein Spindly

      See identical proteins and their annotated locations for NP_001029310.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105812
      UniProtKB/Swiss-Prot
      Q3KR99
      UniProtKB/TrEMBL
      A6HDI3
      Related
      ENSRNOP00000009648.4, ENSRNOT00000009648.8
      Conserved Domains (1) summary
      cl19219
      Location:265351
      DUF342; Protein of unknown function (DUF342)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      19773456..19798341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246104.3XP_006246166.1  protein Spindly isoform X1

      See identical proteins and their annotated locations for XP_006246166.1

      UniProtKB/Swiss-Prot
      Q3KR99
      UniProtKB/TrEMBL
      A6HDI3
      Conserved Domains (1) summary
      cl19219
      Location:265351
      DUF342; Protein of unknown function (DUF342)
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