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    Fancl FA complementation group L [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305600, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fanclprovided by RGD
    Official Full Name
    FA complementation group Lprovided by RGD
    Primary source
    RGD:1311427
    See related
    EnsemblRapid:ENSRNOG00000027249 AllianceGenome:RGD:1311427
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin protein ligase activity and ubiquitin protein ligase binding activity. Predicted to be involved in DNA repair and protein monoubiquitination. Predicted to act upstream of or within gamete generation and regulation of cell population proliferation. Predicted to be located in chromatin; nuclear body; and nuclear envelope. Predicted to be part of Fanconi anaemia nuclear complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group L. Orthologous to human FANCL (FA complementation group L). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 65.1), Spleen (RPKM 48.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fancl in Genome Data Viewer
    Location:
    14q22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (104449403..104515297)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (100249733..100317958)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (110675306..110740880)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein A11, pseudogene 2 Neighboring gene U1 spliceosomal RNA Neighboring gene VRK serine/threonine kinase 2 Neighboring gene uncharacterized LOC134481807 Neighboring gene uncharacterized LOC120096700

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure of the human FANCL RING-Ube2T complex reveals determinants of cognate E3-E2 selection. Hodson C, et al. Structure, 2014 Feb 4. PMID 24389026, Free PMC Article
    2. UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation. Machida YJ, et al. Mol Cell, 2006 Aug. PMID 16916645
    3. A novel gene, Pog, is necessary for primordial germ cell proliferation in the mouse and underlies the germ cell deficient mutation, gcd. Agoulnik AI, et al. Hum Mol Genet, 2002 Nov 15. PMID 12417526
    4. FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL. Longerich S, et al. J Biol Chem, 2009 Aug 28. PMID 19589784, Free PMC Article
    5. Mouse GGN1 and GGN3, two germ cell-specific proteins from the single gene Ggn, interact with mouse POG and play a role in spermatogenesis. Lu B, et al. J Biol Chem, 2003 May 2. PMID 12574169

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gamete generation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interstrand cross-link repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein monoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Fanconi anaemia nuclear complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase FANCL
    Names
    Fanconi anemia, complementation group L
    NP_001178613.1
    XP_006251659.3
    XP_038948041.1
    XP_038948042.2
    XP_063129351.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191684.1 → NP_001178613.1  E3 ubiquitin-protein ligase FANCL

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      D3ZAU3
      Related
      ENSRNOP00000105811.1, ENSRNOT00000143426.1
      Conserved Domains (2) summary
      pfam09765
      Location:15 → 295
      WD-3; WD-repeat region
      pfam11793
      Location:303 → 371
      FANCL_C; FANCL C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      104449403..104515297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092114.2 → XP_038948042.2  E3 ubiquitin-protein ligase FANCL isoform X2

    2. XM_063273281.1 → XP_063129351.1  E3 ubiquitin-protein ligase FANCL isoform X4

    3. XM_039092113.2 → XP_038948041.1  E3 ubiquitin-protein ligase FANCL isoform X3

      Conserved Domains (3) summary
      pfam11793
      Location:230 → 298
      FANCL_C; FANCL C-terminal domain
      pfam18890
      Location:39 → 124
      FANCL_d2; FANCL UBC-like domain 2
      pfam18891
      Location:127 → 222
      FANCL_d3; FANCL UBC-like domain 3

    4. XM_006251597.5 → XP_006251659.3  E3 ubiquitin-protein ligase FANCL isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUP0, D3ZAU3
      Related
      ENSRNOP00000082519.1, ENSRNOT00000102802.2
    Nucleotide Protein Strain
    Heading Accession and Version

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