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    Nr2f2 nuclear receptor subfamily 2, group F, member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 113984, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nr2f2provided by RGD
    Official Full Name
    nuclear receptor subfamily 2, group F, member 2provided by RGD
    Primary source
    RGD:69305
    See related
    EnsemblRapid:ENSRNOG00000010308 AllianceGenome:RGD:69305
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tfcoup2
    Summary
    Enables sequence-specific DNA binding activity. Involved in positive regulation of systemic arterial blood pressure; regulation of DNA-templated transcription; and response to estradiol. Predicted to be located in cytosol and nucleoplasm. Used to study hypertension. Human ortholog(s) of this gene implicated in 46,XX sex reversal 5. Orthologous to human NR2F2 (nuclear receptor subfamily 2 group F member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 101.8), Spleen (RPKM 53.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nr2f2 in Genome Data Viewer
    Location:
    1q31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (133419161..133434290, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (124008282..124022521, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (131447671..131465749, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484900 Neighboring gene DDB1 and CUL4 associated factor 12, pseudogene 1 Neighboring gene uncharacterized LOC102553173 Neighboring gene uncharacterized LOC102553329 Neighboring gene uncharacterized LOC134485134 Neighboring gene serine and arginine rich splicing factor 7, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding  
    enables DNA-binding transcription factor activity  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables nuclear receptor activity  
    enables nuclear receptor activity  
    enables nuclear receptor activity  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables retinoic acid binding  
    enables retinoic acid binding  
    enables retinoic acid binding  
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific DNA binding  
    enables zinc ion binding  
    Items 1 - 25 of 33
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior pattern specification  
    acts_upstream_of_or_within blood vessel morphogenesis  
    involved_in cell differentiation  
    involved_in female gonad development  
    involved_in female gonad development  
    acts_upstream_of_or_within fertilization  
    acts_upstream_of_or_within forebrain development  
    acts_upstream_of_or_within in utero embryonic development  
    acts_upstream_of_or_within interneuron migration  
    involved_in intracellular receptor signaling pathway  
    involved_in lymph vessel development  
    involved_in lymphatic endothelial cell fate commitment  
    acts_upstream_of_or_within maternal placenta development  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity  
    involved_in negative regulation of endothelial cell migration  
    involved_in negative regulation of endothelial cell proliferation  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in nervous system development  
    acts_upstream_of_or_within neuron migration  
    acts_upstream_of_or_within placenta blood vessel development  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of systemic arterial blood pressure PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within radial pattern formation  
    involved_in regulation of DNA-templated transcription PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II  
    involved_in response to estradiol PubMed 
    acts_upstream_of_or_within skeletal muscle tissue development  
    acts_upstream_of_or_within trophoblast giant cell differentiation  
    Items 1 - 25 of 33
    Component Evidence Code Pubs
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    COUP transcription factor 2
    Names
    ARP-1
    COUP transcription factor II
    COUP-TF II
    COUP-TF2
    COUPb
    apolipoprotein A-I regulatory protein 1
    apolipoprotein AI regulatory protein 1
    ovalbumin upstream promoter beta nuclear receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080778.2NP_542956.1  COUP transcription factor 2

      See identical proteins and their annotated locations for NP_542956.1

      Status: PROVISIONAL

      Source sequence(s)
      AF003944
      UniProtKB/Swiss-Prot
      O09018
      UniProtKB/TrEMBL
      A0A8I6A7N1, A6JBW1
      Related
      ENSRNOP00000014152.1, ENSRNOT00000014152.5
      Conserved Domains (2) summary
      cd06948
      Location:177411
      NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
      cd06958
      Location:79151
      NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      133419161..133434290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229366.5XP_006229428.1  COUP transcription factor 2 isoform X1

      See identical proteins and their annotated locations for XP_006229428.1

      UniProtKB/TrEMBL
      A0A0G2K1W0, A6JBW0
      Related
      ENSRNOP00000072005.1, ENSRNOT00000084336.3
      Conserved Domains (1) summary
      cd06948
      Location:44278
      NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
    2. XM_017588643.3XP_017444132.1  COUP transcription factor 2 isoform X3

      Conserved Domains (1) summary
      cd06948
      Location:24258
      NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
    3. XM_039105995.2XP_038961923.1  COUP transcription factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZLR6
      Conserved Domains (1) summary
      cd06948
      Location:34268
      NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
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