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    Cnksr2 connector enhancer of kinase suppressor of Ras 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59322, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cnksr2provided by RGD
    Official Full Name
    connector enhancer of kinase suppressor of Ras 2provided by RGD
    Primary source
    RGD:708454
    See related
    EnsemblRapid:ENSRNOG00000007014 AllianceGenome:RGD:708454
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables identical protein binding activity. Involved in postsynaptic specialization organization. Located in neuronal cell body and postsynaptic membrane. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in syndromic X-linked mental retardation Hough type. Orthologous to human CNKSR2 (connector enhancer of kinase suppressor of Ras 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 247.4), Muscle (RPKM 29.9) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Cnksr2 in Genome Data Viewer
    Location:
    Xq21
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (40722843..40971730)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (36908135..37148337)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (39711001..39953860)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene NME/NM23 nucleoside diphosphate kinase 1, pseudogene 1 Neighboring gene kelch-like family member 34 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene small muscle protein, X-linked

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding PubMed 
    enables protein binding PubMed 
    enables protein kinase binding  
    Component Evidence Code Pubs
    located_in cytoplasm  
    is_active_in extrinsic component of postsynaptic density membrane PubMed 
    is_active_in extrinsic component of postsynaptic density membrane PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    located_in membrane  
    located_in neuronal cell body PubMed 
    located_in plasma membrane  
    located_in postsynaptic density  
    located_in postsynaptic membrane PubMed 

    General protein information

    Preferred Names
    connector enhancer of kinase suppressor of ras 2
    Names
    CNK homolog protein 2
    CNK2
    connector enhancer of KSR 2
    maguin
    maguin-1
    maguin-2
    membrane-associated guanylate kinase-interacting protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113366.1NP_001106837.1  connector enhancer of kinase suppressor of ras 2 isoform 1

      See identical proteins and their annotated locations for NP_001106837.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AF102853, AF102854, JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q9R093, Q9Z1T4
      UniProtKB/TrEMBL
      A6IPN9
      Related
      ENSRNOP00000009802.3, ENSRNOT00000009802.7
      Conserved Domains (8) summary
      cd09511
      Location:876
      SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
      smart00454
      Location:873
      SAM; Sterile alpha motif
      cd00992
      Location:222294
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01260
      Location:559672
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:573669
      PH; PH domain
      pfam06663
      Location:341561
      DUF1170; Protein of unknown function (DUF1170)
      pfam10534
      Location:84176
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
      pfam15499
      Location:139218
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
    2. NM_021686.3NP_067718.1  connector enhancer of kinase suppressor of ras 2 isoform 2

      See identical proteins and their annotated locations for NP_067718.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 3' sequence, as compared to variant 1. The resulting isoform (2) has a shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AF102854, JAXUCZ010000021
      UniProtKB/TrEMBL
      A6IPP1
      Related
      ENSRNOP00000071915.2, ENSRNOT00000080512.3
      Conserved Domains (8) summary
      cd09511
      Location:876
      SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
      smart00454
      Location:873
      SAM; Sterile alpha motif
      cd00992
      Location:222294
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01260
      Location:559672
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:573669
      PH; PH domain
      pfam06663
      Location:341561
      DUF1170; Protein of unknown function (DUF1170)
      pfam10534
      Location:84176
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
      pfam15499
      Location:139218
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      40722843..40971730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017602144.3XP_017457633.1  connector enhancer of kinase suppressor of ras 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A0Z8, A6IPP0
      Related
      ENSRNOP00000084300.1, ENSRNOT00000095688.2
      Conserved Domains (8) summary
      cd09511
      Location:876
      SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
      smart00454
      Location:873
      SAM; Sterile alpha motif
      cd00992
      Location:222270
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01260
      Location:510623
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:524620
      PH; PH domain
      pfam06663
      Location:292512
      DUF1170; Protein of unknown function (DUF1170)
      pfam10534
      Location:84176
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
      pfam15499
      Location:139218
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
    2. XM_063280272.1XP_063136342.1  connector enhancer of kinase suppressor of ras 2 isoform X4

    3. XM_039100001.2XP_038955929.1  connector enhancer of kinase suppressor of ras 2 isoform X3

      Conserved Domains (5) summary
      cd09511
      Location:876
      SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
      cd00992
      Location:222270
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01260
      Location:480593
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam06663
      Location:290408
      DUF1170; Protein of unknown function (DUF1170)
      pfam10534
      Location:84176
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
    4. XM_008773224.4XP_008771446.1  connector enhancer of kinase suppressor of ras 2 isoform X1

      Related
      ENSRNOP00000103907.1, ENSRNOT00000149603.1
      Conserved Domains (8) summary
      cd09511
      Location:876
      SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily
      smart00454
      Location:873
      SAM; Sterile alpha motif
      cd00992
      Location:222294
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01260
      Location:529642
      PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
      pfam00169
      Location:543639
      PH; PH domain
      pfam06663
      Location:341531
      DUF1170; Protein of unknown function (DUF1170)
      pfam10534
      Location:84176
      CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
      pfam15499
      Location:139218
      Peptidase_C98; Ubiquitin-specific peptidase-like, SUMO isopeptidase
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