Hyou1 hypoxia up-regulated 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hyou1provided by RGD
Official Full Name: hypoxia up-regulated 1provided by RGD
Primary source: RGD:621146
See related: EnsemblRapid:ENSRNOG00000010944 AllianceGenome:RGD:621146
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cab140; Orp150
Summary: Predicted to enable adenyl-nucleotide exchange factor activity. Involved in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway and response to hypoxia. Located in smooth endoplasmic reticulum. Human ortholog(s) of this gene implicated in immunodeficiency 59. Orthologous to human HYOU1 (hypoxia up-regulated 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 375.6), Liver (RPKM 349.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (53602882..53614998)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (44706073..44718189)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (48699796..48711912)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

150-kDa oxygen-regulated protein (ORP150) levels were significantly increased in rat retinas after induction of diabetes. Vascular endothelial growth factor (VEGF) and the pro-inflammatory cytokines interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) induced upregulation of ORP150 in HRMEC.
Title: Association of 150-kDa oxygen-regulated protein with vascular endothelial growth factor in proliferative diabetic retinopathy.
Data reveal that Grp170 participates in preparing mutant proinsulin for degradation while enabling wild-type proinsulin escape from the endoplasmic reticulum.
Title: Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in Parallel With Restoration of Wild-Type Insulin Secretion.
LPA promotes VEGF secretion at the post-translation level by up-regulating ORP150 expression.
Title: Lysophosphatidic acid promotes secretion of VEGF by increasing expression of 150-kD Oxygen-regulated protein (ORP150) in mesenchymal stem cells.
Results imply a probable role of ORP150 in the changes in appearance and function of pancreatic beta cells following acute necrotizing pancreatitis, through the pathway of endoplasmic reticulum stress.
Title: Effects of ORP150 on appearance and function of pancreatic beta cells following acute necrotizing pancreatitis.
These data reveal a novel cellular localization for ORP150 and that mitochondrial ORP150 is upregulated by CHOP/GADD153 in response to mitochondrial and ER stress. Our data also reveal that ORP150 is a substrate for mitochondrial calpain 10.
Title: Targeting of the molecular chaperone oxygen-regulated protein 150 (ORP150) to mitochondria and its induction by cellular stress.
role for the protein both in preventing cardiomyocyte death and in preserving contractile function after ischemic damage
Title: 150-kDa oxygen-regulated protein attenuates myocardial ischemia-reperfusion injury in rat heart.
ER stress proteins (GRP78 and ORP150), respectively) were upregulated at PTCs in experimental proteinuric rats.
Title: Albumin induces endoplasmic reticulum stress and apoptosis in renal proximal tubular cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables adenyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ischemia	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to ischemia	ISO Inferred from Sequence Orthology more info
involved_in response to ischemia	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
part_of endoplasmic reticulum chaperone complex	IBA Inferred from Biological aspect of Ancestor more info
part_of endoplasmic reticulum chaperone complex	IEA Inferred from Electronic Annotation more info
part_of endoplasmic reticulum chaperone complex	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in smooth endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: hypoxia up-regulated protein 1

Names: 150 kDa oxygen-regulated protein; ORP-150; oxygen regulated protein (150kD)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034028.1 → NP_001029200.1 hypoxia up-regulated protein 1 precursor

See identical proteins and their annotated locations for NP_001029200.1

Status: VALIDATED

Source sequence(s)

BC065310, CB691248

UniProtKB/TrEMBL

A0A8J8XLC6, F1LN18, Q6P136

Conserved Domains (3) summary

cd10230
Location:36 → 424

HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins

pfam00012
Location:35 → 700

HSP70; Hsp70 protein

pfam06459
Location:549 → 706

RR_TM4-6; Ryanodine Receptor TM 4-6
NM_138867.2 → NP_620222.2 hypoxia up-regulated protein 1 precursor

See identical proteins and their annotated locations for NP_620222.2

Status: VALIDATED

Source sequence(s)

BC065310, U41853

UniProtKB/TrEMBL

A0A8J8XLC6, F1LN18, Q6P136

Conserved Domains (3) summary

cd10230
Location:36 → 424

HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins

pfam00012
Location:35 → 700

HSP70; Hsp70 protein

pfam06459
Location:549 → 706

RR_TM4-6; Ryanodine Receptor TM 4-6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

53602882..53614998

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006242885.4 → XP_006242947.1 hypoxia up-regulated protein 1 isoform X1

See identical proteins and their annotated locations for XP_006242947.1

UniProtKB/TrEMBL

A0A8J8XLC6, F1LN18, Q6P136

Related

ENSRNOP00000039172.6, ENSRNOT00000044613.6

Conserved Domains (3) summary

cd10230
Location:36 → 424

HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins

pfam00012
Location:35 → 700

HSP70; Hsp70 protein

pfam06459
Location:549 → 706

RR_TM4-6; Ryanodine Receptor TM 4-6
XM_006242884.4 → XP_006242946.1 hypoxia up-regulated protein 1 isoform X1

See identical proteins and their annotated locations for XP_006242946.1

UniProtKB/TrEMBL

A0A8J8XLC6, F1LN18, Q6P136

Conserved Domains (3) summary

cd10230
Location:36 → 424

HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins

pfam00012
Location:35 → 700

HSP70; Hsp70 protein

pfam06459
Location:549 → 706

RR_TM4-6; Ryanodine Receptor TM 4-6