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    Cops5 COP9 signalosome subunit 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312916, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cops5provided by RGD
    Official Full Name
    COP9 signalosome subunit 5provided by RGD
    Primary source
    RGD:1310301
    See related
    EnsemblRapid:ENSRNOG00000006499 AllianceGenome:RGD:1310301
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme binding activity; macrophage migration inhibitory factor binding activity; and ubiquitin-like protein peptidase activity. Predicted to be involved in several processes, including regulation of DNA-templated transcription; regulation of apoptotic process; and regulation of intracellular signal transduction. Predicted to act upstream of or within regulation of cell cycle. Predicted to be located in several cellular components, including nucleoplasm; perinuclear region of cytoplasm; and synaptic vesicle. Predicted to be part of COP9 signalosome. Predicted to be active in cytoplasm. Orthologous to human COPS5 (COP9 signalosome subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 529.0), Testes (RPKM 471.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cops5 in Genome Data Viewer
    Location:
    5q11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (13975198..13993391)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (9192233..9210498)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (8876090..8894345)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ARF guanine nucleotide exchange factor 1 Neighboring gene uncharacterized LOC134486914 Neighboring gene uncharacterized LOC134486913 Neighboring gene centrosome and spindle pole associated protein 1 Neighboring gene RNA, U6 small nuclear 1297 Neighboring gene protein phosphatase 1, regulatory subunit 42

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Porcine JAB1 significantly enhances apoptosis induced by staurosporine. Jiang P, et al. Cell Death Dis, 2013 Oct 3. PMID 24091666, Free PMC Article
    2. COP9-associated CSN5 regulates exosomal protein deubiquitination and sorting. Liu Y, et al. Am J Pathol, 2009 Apr. PMID 19246649, Free PMC Article
    3. JAB1 participates in unfolded protein responses by association and dissociation with IRE1. Oono K, et al. Neurochem Int, 2004 Oct. PMID 15234121
    4. Fank1 interacts with Jab1 and regulates cell apoptosis via the AP-1 pathway. Wang H, et al. Cell Mol Life Sci, 2011 Jun. PMID 20978819, Free PMC Article
    5. Down-regulation of the cyclin-dependent kinase inhibitor p57 is mediated by Jab1/Csn5 in hepatocarcinogenesis. Guo H, et al. Hepatology, 2016 Mar. PMID 26606000

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Jab1 provides a novel signal transduction pathway for 5-HT(6)R and may play an important role in 5-HT(6)R-mediated behavior changes in the brain
      Title: Physical interaction of Jab1 with human serotonin 6 G-protein-coupled receptor and their possible roles in cell survival.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112728

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables deNEDDylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables macrophage migration inhibitory factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal-dependent deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in exosomal secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deneddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of IRE1-mediated unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reproductive process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    COP9 signalosome complex subunit 5
    Names
    COP9 (constitutive photomorphogenic) homolog, subunit 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025695.1 → NP_001020866.1  COP9 signalosome complex subunit 5

      See identical proteins and their annotated locations for NP_001020866.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098736
      UniProtKB/TrEMBL
      A0A8I5ZYE7, Q4KM69
      Related
      ENSRNOP00000008877.5, ENSRNOT00000008877.8
      Conserved Domains (1) summary
      cd08069
      Location:44 → 314
      MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      13975198..13993391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237758.5 → XP_006237820.1  COP9 signalosome complex subunit 5 isoform X1

      Conserved Domains (1) summary
      cd08069
      Location:33 → 297
      MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5
    Nucleotide Protein Strain
    Heading Accession and Version

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