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    C1qtnf5 C1q and TNF related 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315598, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C1qtnf5provided by RGD
    Official Full Name
    C1q and TNF related 5provided by RGD
    Primary source
    RGD:1308802
    See related
    EnsemblRapid:ENSRNOG00000007613 AllianceGenome:RGD:1308802
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Adie
    Summary
    Predicted to enable identical protein binding activity. Predicted to act upstream of or within inner ear development and protein secretion. Predicted to be located in several cellular components, including apical plasma membrane; bicellular tight junction; and lateral plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in cell projection; extracellular space; and plasma membrane. Human ortholog(s) of this gene implicated in late-onset retinal degeneration. Orthologous to human C1QTNF5 (C1q and TNF related 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 88.1), Uterus (RPKM 84.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See C1qtnf5 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53347754..53349912)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44450934..44453075)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48443515..48445639)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 2 Neighboring gene membrane frizzled-related protein Neighboring gene ring finger protein 26 Neighboring gene uncharacterized LOC120094132

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CTRP5 ameliorates palmitate-induced apoptosis and insulin resistance through activation of AMPK and fatty acid oxidation. Yang WM, et al. Biochem Biophys Res Commun, 2014 Sep 26. PMID 25195818
    2. C1q tumor necrosis factor alpha-related protein isoform 5 is increased in mitochondrial DNA-depleted myocytes and activates AMP-activated protein kinase. Park SY, et al. J Biol Chem, 2009 Oct 9. PMID 19651784, Free PMC Article
    3. CTRP5 is a membrane-associated and secretory protein in the RPE and ciliary body and the S163R mutation of CTRP5 impairs its secretion. Mandal MN, et al. Invest Ophthalmol Vis Sci, 2006 Dec. PMID 17122142
    4. Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions. Wong GW, et al. Biochem J, 2008 Dec 1. PMID 18783346, Free PMC Article
    5. Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly. Lu CC, et al. J Neurosci, 2011 Jul 27. PMID 21795542, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CTRP5 ameliorates palmitate-induced apoptosis and insulin resistance through activation of AMPK and fatty acid oxidation.
      Title: CTRP5 ameliorates palmitate-induced apoptosis and insulin resistance through activation of AMPK and fatty acid oxidation.
    2. These results highlight C1QTNF5 as a putative biomarker for mitochondrial dysfunction and a potent activator of AMPK.
      Title: C1q tumor necrosis factor alpha-related protein isoform 5 is increased in mitochondrial DNA-depleted myocytes and activates AMP-activated protein kinase.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109436

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within inner ear development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in transport vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    complement C1q tumor necrosis factor-related protein 5
    Names
    C1q and tumor necrosis factor related protein 5
    adiponectin e

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012123.1 → NP_001012123.1  complement C1q tumor necrosis factor-related protein 5 precursor

      Status: PROVISIONAL

      Source sequence(s)
      BC089992
      UniProtKB/Swiss-Prot
      Q5FVH0
      UniProtKB/TrEMBL
      A0A3B0ITJ1
      Conserved Domains (2) summary
      pfam01391
      Location:29 → 95
      Collagen; Collagen triple helix repeat (20 copies)
      pfam00386
      Location:105 → 232
      C1q; C1q domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      53347754..53349912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081421.2 → XP_038937349.1  complement C1q tumor necrosis factor-related protein 5 isoform X1

      Related
      ENSRNOP00000010127.5, ENSRNOT00000010127.7
      Conserved Domains (2) summary
      pfam00386
      Location:198 → 325
      C1q; C1q domain
      pfam01391
      Location:122 → 188
      Collagen; Collagen triple helix repeat (20 copies)

    2. XM_017595622.3 → XP_017451111.1  complement C1q tumor necrosis factor-related protein 5 isoform X2

      UniProtKB/Swiss-Prot
      Q5FVH0
      UniProtKB/TrEMBL
      A0A3B0ITJ1
      Conserved Domains (2) summary
      pfam01391
      Location:29 → 95
      Collagen; Collagen triple helix repeat (20 copies)
      pfam00386
      Location:105 → 232
      C1q; C1q domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FVH0.1 GenPept UniProtKB/Swiss-Prot:Q5FVH0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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