Dnase1l1 deoxyribonuclease 1-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnase1l1provided by RGD
Official Full Name: deoxyribonuclease 1-like 1provided by RGD
Primary source: RGD:1359588
See related: EnsemblRapid:ENSRNOG00000055641 AllianceGenome:RGD:1359588
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA binding activity and deoxyribonuclease I activity. Predicted to be involved in DNA catabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in nucleus. Orthologous to human DNASE1L1 (deoxyribonuclease 1 like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 280.6), Lung (RPKM 126.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq37

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (157208230..157216812, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (152056942..152065518, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (156429521..156438066)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH137735 (e-PCR)
- UniSTS:219822

RH139827 (e-PCR)
- UniSTS:221911

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA nuclease activity	IEA Inferred from Electronic Annotation more info
enables deoxyribonuclease I activity	IBA Inferred from Biological aspect of Ancestor more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: deoxyribonuclease-1-like 1

Names: DNase I-like 1; DNase X; deoxyribonuclease I-like 1

NP_001014245.2

EC 3.1.21.-

XP_006229664.1

EC 3.1.21.-

XP_038955853.1

EC 3.1.21.-

XP_038955854.1

EC 3.1.21.-

XP_038955855.1

EC 3.1.21.-

XP_038955856.1

EC 3.1.21.-

XP_038955857.1

EC 3.1.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014223.3 → NP_001014245.2 deoxyribonuclease-1-like 1 precursor

See identical proteins and their annotated locations for NP_001014245.2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q2QDE7

UniProtKB/TrEMBL

A6KRR9, Q6AYF0

Related

ENSRNOP00000073157.1, ENSRNOT00000083203.3

Conserved Domains (1) summary

cl00490
Location:24 → 288

EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

157208230..157216812 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006229602.4 → XP_006229664.1 deoxyribonuclease-1-like 1 isoform X1

See identical proteins and their annotated locations for XP_006229664.1

UniProtKB/TrEMBL

A6KRS0, Q6AYF0

Related

ENSRNOP00000089112.2, ENSRNOT00000119460.2

Conserved Domains (1) summary

cl00490
Location:24 → 262

EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
XM_039099926.2 → XP_038955854.1 deoxyribonuclease-1-like 1 isoform X4

UniProtKB/TrEMBL

A0A8I6A7H1, Q6AYF0

Conserved Domains (1) summary

cl00490
Location:24 → 255

EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
XM_039099925.2 → XP_038955853.1 deoxyribonuclease-1-like 1 isoform X2

UniProtKB/TrEMBL

Q6AYF0

Conserved Domains (1) summary

cl00490
Location:24 → 276

EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
XM_039099927.2 → XP_038955855.1 deoxyribonuclease-1-like 1 isoform X3

Conserved Domains (1) summary

cl00490
Location:24 → 250

EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
XM_039099929.2 → XP_038955857.1 deoxyribonuclease-1-like 1 isoform X5

Conserved Domains (1) summary

cl00490
Location:23 → 191

EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
XM_039099928.2 → XP_038955856.1 deoxyribonuclease-1-like 1 isoform X5

Conserved Domains (1) summary

cl00490
Location:23 → 191

EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily