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    Gsap gamma-secretase activating protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311984, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gsapprovided by RGD
    Official Full Name
    gamma-secretase activating proteinprovided by RGD
    Primary source
    RGD:1563271
    See related
    EnsemblRapid:ENSRNOG00000028801 AllianceGenome:RGD:1563271
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pion
    Summary
    Predicted to enable amyloid-beta binding activity. Predicted to be involved in positive regulation of amyloid-beta formation and regulation of proteolysis. Predicted to be active in trans-Golgi network. Orthologous to human GSAP (gamma-secretase activating protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 130.5), Lung (RPKM 106.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gsap in Genome Data Viewer
    Location:
    4q11
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (14705237..14800057, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (13813046..13907875, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (10423090..10517887, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 146 Neighboring gene fibrinogen-like 2 Neighboring gene uncharacterized LOC120102212 Neighboring gene neuroepithelial cell transforming 1, pseudogene 1 Neighboring gene small nucleolar RNA SNORA40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-β generation. Hussain I, et al. J Biol Chem, 2013 Jan 25. PMID 23209290, Free PMC Article
    2. Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease. He G, et al. Nature, 2010 Sep 2. PMID 20811458, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. gamma-secretase activating protein (GSAP) and imatinib have roles in the regulation of gamma-secretase activity and amyloid-beta generation
      Title: The role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-β generation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of amyloid-beta formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of amyloid-beta formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    gamma-secretase-activating protein
    Names
    pigeon homolog
    protein pigeon homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395028.2 → NP_001381957.1  gamma-secretase-activating protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2JWZ3, A0A8I6A0P7, A6K5C2
      Related
      ENSRNOP00000070072.1, ENSRNOT00000083964.3
      Conserved Domains (1) summary
      pfam14959
      Location:634 → 741
      GSAP-16; gamma-Secretase-activating protein C-term

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      14705237..14800057 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762649.4 → XP_008760871.1  gamma-secretase-activating protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6A0P7
      Conserved Domains (1) summary
      pfam14959
      Location:634 → 741
      GSAP-16; gamma-Secretase-activating protein C-term

    2. XM_063285956.1 → XP_063142026.1  gamma-secretase-activating protein isoform X2

      UniProtKB/TrEMBL
      A6K5C3, D3ZPQ9

    3. XM_039107498.2 → XP_038963426.1  gamma-secretase-activating protein isoform X3

    RNA

    1. XR_005503210.2 RNA Sequence

    2. XR_005503209.2 RNA Sequence

    3. XR_010065635.1 RNA Sequence

    4. XR_010065636.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107845.1: Suppressed sequence

      Description
      NM_001107845.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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