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    Clec1b C-type lectin domain family 1, member B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500336, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Clec1bprovided by RGD
    Official Full Name
    C-type lectin domain family 1, member Bprovided by RGD
    Primary source
    RGD:1563517
    See related
    EnsemblRapid:ENSRNOG00000057335 AllianceGenome:RGD:1563517
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563517
    Summary
    Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in platelet formation and signal transduction. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human CLEC1B (C-type lectin domain family 1 member B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 49.6), Lung (RPKM 19.0) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Clec1b in Genome Data Viewer
    Location:
    4q42
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (164533987..164542320)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (162847978..162856291)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (163161941..163170470)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 12, member A Neighboring gene chromatin target of PRMT1-like 1 Neighboring gene C-type lectin domain family 12, member B Neighboring gene C-type lectin domain containing 9A Neighboring gene C-type lectin domain family 1, member A Neighboring gene uncharacterized LOC120102409

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells. Colonna M, et al. Eur J Immunol, 2000 Feb. PMID 10671229
    2. G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2. Mori J, et al. J Biol Chem, 2008 Dec 19. PMID 18955485, Free PMC Article
    3. The complete inventory of receptors encoded by the rat natural killer cell gene complex. Flornes LM, et al. Immunogenetics, 2010 Aug. PMID 20544345, Free PMC Article
    4. Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function. Mazharian A, et al. Sci Signal, 2012 Oct 30. PMID 23112346, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in platelet formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within platelet formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    C-type lectin domain family 1 member B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191978.3 → NP_001178907.1  C-type lectin domain family 1 member B

      See identical proteins and their annotated locations for NP_001178907.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IM43, D3ZJD8
      Related
      ENSRNOP00000071442.1, ENSRNOT00000082537.3
      Conserved Domains (1) summary
      cd03593
      Location:102 → 218
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      164533987..164542320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592835.3 → XP_017448324.1  C-type lectin domain family 1 member B isoform X4

      UniProtKB/TrEMBL
      A0A8I6A8F5, A6IM44
      Related
      ENSRNOP00000087395.1, ENSRNOT00000102030.2

    2. XM_006237089.5 → XP_006237151.1  C-type lectin domain family 1 member B isoform X2

      UniProtKB/TrEMBL
      A0A8I6GBW7
      Related
      ENSRNOP00000085142.1, ENSRNOT00000111167.2
      Conserved Domains (1) summary
      cd03593
      Location:70 → 186
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    3. XM_006237088.5 → XP_006237150.1  C-type lectin domain family 1 member B isoform X1

      Conserved Domains (1) summary
      cd03593
      Location:101 → 217
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    4. XM_006237090.5 → XP_006237152.1  C-type lectin domain family 1 member B isoform X3

      Conserved Domains (1) summary
      cd03593
      Location:69 → 185
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    Nucleotide Protein Strain
    Heading Accession and Version

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