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    Clta clathrin, light chain A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83800, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cltaprovided by RGD
    Official Full Name
    clathrin, light chain Aprovided by RGD
    Primary source
    RGD:70919
    See related
    EnsemblRapid:ENSRNOG00000014635 AllianceGenome:RGD:70919
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LCA1; LCA2; LCA3
    Summary
    Enables GTPase binding activity and peptide binding activity. Involved in synaptic vesicle endocytosis. Located in clathrin-coated pit and clathrin-coated vesicle. Part of clathrin coat. Is active in postsynaptic endocytic zone; presynaptic endocytic zone membrane; and synaptic vesicle membrane. Orthologous to human CLTA (clathrin light chain A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 442.1), Spleen (RPKM 305.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Clta in Genome Data Viewer
    Location:
    5q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (63022046..63059223)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (58244253..58263480)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (59490689..59509139)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene GLI pathogenesis-related 2 Neighboring gene calicin Neighboring gene glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Neighboring gene small ribosomal subunit protein eS12-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC105384

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase binding PubMed 
    enables clathrin heavy chain binding  
    enables clathrin heavy chain binding  
    enables peptide binding PubMed 
    enables protein binding PubMed 
    enables protein-containing complex binding PubMed 
    enables structural molecule activity  
    Process Evidence Code Pubs
    involved_in cell division  
    involved_in clathrin coat assembly  
    involved_in clathrin-dependent endocytosis  
    involved_in endocytosis PubMed 
    involved_in intracellular protein transport  
    involved_in synaptic vesicle endocytosis PubMed 
    involved_in synaptic vesicle endocytosis PubMed 
    involved_in synaptic vesicle endocytosis PubMed 
    involved_in vesicle-mediated transport  
    Items 1 - 20 of 23
    Component Evidence Code Pubs
    part_of clathrin coat PubMed 
    part_of clathrin coat  
    part_of clathrin coat of coated pit  
    part_of clathrin coat of coated pit PubMed 
    part_of clathrin coat of trans-Golgi network vesicle  
    part_of clathrin complex  
    part_of clathrin vesicle coat  
    part_of clathrin vesicle coat PubMed 
    located_in clathrin-coated endocytic vesicle membrane  
    located_in clathrin-coated pit PubMed 
    located_in clathrin-coated vesicle PubMed 
    located_in cytoplasmic vesicle  
    is_active_in glutamatergic synapse  
    is_active_in plasma membrane  
    is_active_in postsynaptic endocytic zone PubMed 
    is_active_in postsynaptic endocytic zone PubMed 
    is_active_in postsynaptic endocytic zone  
    is_active_in postsynaptic endocytic zone cytoplasmic component  
    is_active_in presynaptic endocytic zone membrane PubMed 
    located_in spindle  
    is_active_in synaptic vesicle membrane  
    is_active_in synaptic vesicle membrane PubMed 
    located_in synaptic vesicle membrane PubMed 
    Items 1 - 20 of 23

    General protein information

    Preferred Names
    clathrin light chain A
    Names
    clathrin, light chain (Lca)
    clathrin, light polypeptide (Lca)
    lca

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031974.1NP_114180.1  clathrin light chain A

      See identical proteins and their annotated locations for NP_114180.1

      Status: PROVISIONAL

      Source sequence(s)
      M15882
      UniProtKB/Swiss-Prot
      P08081
      UniProtKB/TrEMBL
      A6IJ63
      Related
      ENSRNOP00000019737.2, ENSRNOT00000019737.7
      Conserved Domains (1) summary
      pfam01086
      Location:20243
      Clathrin_lg_ch; Clathrin light chain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      63022046..63059223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238104.4XP_006238166.1  clathrin light chain A isoform X1

      See identical proteins and their annotated locations for XP_006238166.1

      UniProtKB/TrEMBL
      A0A0G2JYW3, A6IJ64
      Related
      ENSRNOP00000070814.1, ENSRNOT00000083068.3
      Conserved Domains (1) summary
      pfam01086
      Location:20231
      Clathrin_lg_ch; Clathrin light chain
    2. XM_006238105.4XP_006238167.1  clathrin light chain A isoform X2

      UniProtKB/TrEMBL
      A0A8I6A7H3
      Related
      ENSRNOP00000089530.1, ENSRNOT00000101159.2
      Conserved Domains (1) summary
      pfam01086
      Location:20225
      Clathrin_lg_ch; Clathrin light chain
    3. XM_006238106.4XP_006238168.1  clathrin light chain A isoform X3

      See identical proteins and their annotated locations for XP_006238168.1

      UniProtKB/TrEMBL
      Q5PPP1
      Related
      ENSRNOP00000035138.4, ENSRNOT00000036366.8
      Conserved Domains (1) summary
      pfam01086
      Location:20213
      Clathrin_lg_ch; Clathrin light chain
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