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    Nherf2 NHERF family PDZ scaffold protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116501, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nherf2provided by RGD
    Official Full Name
    NHERF family PDZ scaffold protein 2provided by RGD
    Primary source
    RGD:620380
    See related
    EnsemblRapid:ENSRNOG00000002997 AllianceGenome:RGD:620380
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    E3karp; Slc9a3r2
    Summary
    Enables low-density lipoprotein particle receptor binding activity and molecular adaptor activity. Involved in inner ear development and positive regulation of monoatomic ion transmembrane transport. Located in apical plasma membrane. Part of protein-containing complex. Biomarker of hypertension. Orthologous to human NHERF2 (NHERF family PDZ scaffold protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 311.8), Heart (RPKM 203.5) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Nherf2 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14167005..14177519, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13662461..13672975, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14003330..14015066, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene polycystin 1, transient receptor potential channel interacting Neighboring gene TSC complex subunit 2 Neighboring gene nth-like DNA glycosylase 1 Neighboring gene neuropeptide W Neighboring gene zinc finger protein 598

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-catenin binding  
    enables beta-catenin binding  
    enables identical protein binding  
    enables identical protein binding  
    enables low-density lipoprotein particle receptor binding PubMed 
    enables molecular adaptor activity  
    enables molecular adaptor activity PubMed 
    enables phosphatase binding  
    enables phosphatase binding  
    enables protein binding PubMed 
    enables protein-membrane adaptor activity  
    enables signaling receptor binding  
    enables signaling receptor binding  
    enables signaling receptor binding  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane  
    located_in apical plasma membrane PubMed 
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in cytoplasm  
    located_in endomembrane system  
    located_in nucleus  
    located_in plasma membrane  
    part_of protein-containing complex PubMed 
    located_in stereocilium  
    located_in stereocilium bundle  

    General protein information

    Preferred Names
    Na(+)/H(+) exchange regulatory cofactor NHE-RF2
    Names
    NHE3 kinase A regulatory protein E3KARP
    NHERF-2
    SIP-1
    SLC9A3 regulator 2
    SRY-interacting protein 1
    TKA-1
    sodium-hydrogen exchanger regulatory factor 2
    sodium/hydrogen exchanger
    solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
    solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
    tyrosine kinase activator protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053811.3NP_446263.2  Na(+)/H(+) exchange regulatory cofactor NHE-RF2

      See identical proteins and their annotated locations for NP_446263.2

      Status: VALIDATED

      Source sequence(s)
      AF294257, CK840521, JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q91Y70, Q920G2
      UniProtKB/TrEMBL
      A6HCU6, G3V6D9
      Related
      ENSRNOP00000004172.2, ENSRNOT00000004172.6
      Conserved Domains (2) summary
      cd00992
      Location:988
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09007
      Location:232337
      EBP50_C; EBP50, C-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      14167005..14177519 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085043.2XP_038940971.1  Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A0E3
      Conserved Domains (2) summary
      cd00992
      Location:1897
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09007
      Location:101206
      EBP50_C; EBP50, C-terminal
    2. XM_006245893.5XP_006245955.1  Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform X1

      See identical proteins and their annotated locations for XP_006245955.1

      UniProtKB/TrEMBL
      A0A8I6A0E3, A6HCU7
      Related
      ENSRNOP00000085544.2, ENSRNOT00000097124.2
      Conserved Domains (2) summary
      cd00992
      Location:38117
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09007
      Location:121226
      EBP50_C; EBP50, C-terminal
    3. XM_039085044.2XP_038940972.1  Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A0E3
      Conserved Domains (2) summary
      cd00992
      Location:1493
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam09007
      Location:97202
      EBP50_C; EBP50, C-terminal
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