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    Zfp36l2 zinc finger protein 36, C3H type-like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298765, updated on 9-Dec-2024

    Summary

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    Symbol
    Zfp36l2provided by RGD
    Full Name
    zinc finger protein 36, C3H type-like 2provided by RGD
    Primary source
    RGD:1308913
    See related
    EnsemblRapid:ENSRNOG00000005067 AllianceGenome:RGD:1308913
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; hemopoiesis; and positive regulation of mRNA catabolic process. Predicted to act upstream of or within hemopoiesis and nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ribonucleoprotein complex. Orthologous to human ZFP36L2 (ZFP36 ring finger protein like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 60.3), Spleen (RPKM 60.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp36l2 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (16242622..16246662)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (10490032..10494073)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (7417416..7423447, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology, MyTH4 and FERM domain containing H2 Neighboring gene uncharacterized LOC134479314 Neighboring gene THADA, armadillo repeat containing Neighboring gene uncharacterized LOC108351166 Neighboring gene synaptophysin-like 1, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors. Zhang L, et al. Nature, 2013 Jul 4. PMID 23748442, Free PMC Article
    2. A computational study of RNA binding and specificity in the tandem zinc finger domain of TIS11d. Morgan BR, et al. Protein Sci, 2010 Jun. PMID 20506496, Free PMC Article
    3. Characterization of DeltaN-Zfp36l2 mutant associated with arrest of early embryonic development and female infertility. Ramos SB. J Biol Chem, 2012 Apr 13. PMID 22367205, Free PMC Article
    4. Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia. Hodson DJ, et al. Nat Immunol, 2010 Aug. PMID 20622884, Free PMC Article
    5. Functional analysis of ZFP36 proteins in keratinocytes. Prenzler F, et al. Eur J Cell Biol, 2016 Aug. PMID 27182009

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA 3'-UTR AU-rich region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell differentiation in thymus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to epidermal growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to fibroblast growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to glucocorticoid stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in definitive hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitotic cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of mRNA stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to wounding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in somatic stem cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in somatic stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mRNA decay activator protein ZFP36L2
    Names
    butyrate response factor 2
    zinc finger protein 36, C3H1 type-like 2
    zinc finger protein 36, C3H1 type-like 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001036626.3 → NP_001031703.2  mRNA decay activator protein ZFP36L2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6H9J7, D3ZHK9
      Related
      ENSRNOP00000006725.5, ENSRNOT00000006725.7
      Conserved Domains (2) summary
      COG5063
      Location:152 → 214
      CTH1; CCCH-type Zn-finger protein [General function prediction only]
      pfam04553
      Location:1 → 129
      Tis11B_N; Tis11B like protein, N-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      16242622..16246662
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008765049.3 → XP_008763271.1  mRNA decay activator protein ZFP36L2 isoform X1

      UniProtKB/TrEMBL
      A6H9J7
      Conserved Domains (2) summary
      pfam00642
      Location:164 → 189
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam04553
      Location:3 → 141
      Tis11B_N; Tis11B like protein, N terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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