Marchf2 membrane associated ring-CH-type finger 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Marchf2provided by RGD
Official Full Name: membrane associated ring-CH-type finger 2provided by RGD
Primary source: RGD:1306395
See related: EnsemblRapid:ENSRNOG00000007769 AllianceGenome:RGD:1306395
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: March2; RNF172; MARCH-II; RGD1306395
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in defense response to symbiont; positive regulation of lysosomal protein catabolic process; and protein ubiquitination. Predicted to be located in several cellular components, including Golgi membrane; cytosol; and endoplasmic reticulum. Orthologous to human MARCHF2 (membrane associated ring-CH-type finger 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 846.5), Heart (RPKM 578.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (15183931..15209988, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (14480605..14507821, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (18559301..18585351, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Depletion of MARCH-II by small interfering RNA perturbed the trans-Golgi network (TGN) localization of syntaxin 6 and TGN38/46
Title: MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antibacterial innate immune response	ISO Inferred from Sequence Orthology more info
involved_in antibacterial innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in antiviral innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lysosomal protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lysosomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in suppression of viral release by host	IEA Inferred from Electronic Annotation more info
involved_in suppression of viral release by host	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase MARCHF2

Names: E3 ubiquitin-protein ligase MARCH2; RING finger protein 172; RING-type E3 ubiquitin transferase MARCH2; RING-type E3 ubiquitin transferase MARCHF2; membrane associated RING-CH finger protein II; membrane-associated RING finger protein 2; membrane-associated RING-CH protein II; membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase; syntaxin-6-binding protein

NP_001029280.1

EC 2.3.2.27

XP_006241188.1

EC 2.3.2.27

XP_006241189.1

EC 2.3.2.27

XP_008763423.1

EC 2.3.2.27

XP_038935345.1

EC 2.3.2.27

XP_063119824.1

EC 2.3.2.27

XP_063119825.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034108.1 → NP_001029280.1 E3 ubiquitin-protein ligase MARCHF2

See identical proteins and their annotated locations for NP_001029280.1

Status: VALIDATED

Source sequence(s)

AI578941, BC088286

UniProtKB/Swiss-Prot

Q5I0I2

UniProtKB/TrEMBL

A0A8I6AGT0, A6KQH7

Conserved Domains (2) summary

pfam00558
Location:173 → 224

Vpu; Vpu protein

cd16808
Location:62 → 113

RING_CH-C4HC3_MARCH2; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH2 (MARCH2)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

15183931..15209988 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008765201.4 → XP_008763423.1 E3 ubiquitin-protein ligase MARCHF2 isoform X4

Conserved Domains (1) summary

smart00744
Location:63 → 110

RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
XM_006241126.4 → XP_006241188.1 E3 ubiquitin-protein ligase MARCHF2 isoform X2

Related

ENSRNOP00000010399.6, ENSRNOT00000010399.9

Conserved Domains (1) summary

smart00744
Location:63 → 110

RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
XM_006241127.5 → XP_006241189.1 E3 ubiquitin-protein ligase MARCHF2 isoform X3

Conserved Domains (1) summary

smart00744
Location:63 → 110

RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
XM_039079417.2 → XP_038935345.1 E3 ubiquitin-protein ligase MARCHF2 isoform X1

Conserved Domains (1) summary

cd16808
Location:62 → 113

RING_CH-C4HC3_MARCH2; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH2 (MARCH2)
XM_063263754.1 → XP_063119824.1 E3 ubiquitin-protein ligase MARCHF2 isoform X5
XM_063263755.1 → XP_063119825.1 E3 ubiquitin-protein ligase MARCHF2 isoform X6

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001012196.2: Suppressed sequence

Description

NM_001012196.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.