Mcm10 minichromosome maintenance 10 replication initiation factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mcm10provided by RGD
Official Full Name: minichromosome maintenance 10 replication initiation factorprovided by RGD
Primary source: RGD:1311330
See related: EnsemblRapid:ENSRNOG00000017981 AllianceGenome:RGD:1311330
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA binding activity; enzyme binding activity; and identical protein binding activity. Predicted to be involved in DNA damage response and DNA replication initiation. Predicted to act upstream of or within cell population proliferation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in nuclear replication fork. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MCM10 (minichromosome maintenance 10 replication initiation factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 73.3), Spleen (RPKM 41.9) and 7 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 17q12.3

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (78172049..78197644)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (73263788..73288346)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (77224218..77245486)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

RH132027 (e-PCR)
- UniSTS:215310

RH132593 (e-PCR)
- UniSTS:215876

BF397898 (e-PCR)
- UniSTS:246358

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA replication origin binding	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication initiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nuclear replication fork	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: protein MCM10 homolog

Names: minichromosome maintenance complex component 10; minichromosome maintenance deficient 10

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107366.1 → NP_001100836.1 protein MCM10 homolog

See identical proteins and their annotated locations for NP_001100836.1

Status: PROVISIONAL

Source sequence(s)

CH473990

UniProtKB/TrEMBL

A6JLZ2, D3Z8C4

Related

ENSRNOP00000024178.5, ENSRNOT00000024178.8

Conserved Domains (2) summary

pfam09329
Location:402 → 447

zf-primase; Primase zinc finger

pfam09332
Location:545 → 887

Mcm10; Mcm10 replication factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

78172049..78197644

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039095781.2 → XP_038951709.1 protein MCM10 homolog isoform X1

Related

ENSRNOP00000103505.1, ENSRNOT00000148655.1

Conserved Domains (3) summary

PHA03247
Location:87 → 283

PHA03247; large tegument protein UL36; Provisional

pfam09329
Location:346 → 391

zf-primase; Primase zinc finger

pfam09332
Location:492 → 831

Mcm10; Mcm10 replication factor
XM_063276495.1 → XP_063132565.1 protein MCM10 homolog isoform X2
XM_039095782.2 → XP_038951710.1 protein MCM10 homolog isoform X3

Conserved Domains (2) summary

pfam09329
Location:46 → 91

zf-primase; Primase zinc finger

pfam09332
Location:192 → 531

Mcm10; Mcm10 replication factor