Evc2 EvC ciliary complex subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Evc2provided by RGD
Official Full Name: EvC ciliary complex subunit 2provided by RGD
Primary source: RGD:1310417
See related: EnsemblRapid:ENSRNOG00000007025 AllianceGenome:RGD:1310417
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in smoothened signaling pathway. Predicted to be located in cilium and nucleus. Predicted to be part of plasma membrane protein complex. Predicted to be active in ciliary membrane. Human ortholog(s) of this gene implicated in Ellis-Van Creveld syndrome and Weyers acrofacial dysostosis. Orthologous to human EVC2 (EvC ciliary complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 37.8), Uterus (RPKM 19.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (77591581..77679286, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (73366832..73454539, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (78128620..78212394, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in smoothened signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in ciliary membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary membrane	ISO Inferred from Sequence Orthology more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of plasma membrane protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of plasma membrane protein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: limbin

Names: Ellis van Creveld syndrome 2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106012.1 → NP_001099482.1 limbin

See identical proteins and their annotated locations for NP_001099482.1

Status: PROVISIONAL

Source sequence(s)

CH473963

UniProtKB/TrEMBL

A6IJW0, D3ZWN3

Related

ENSRNOP00000103995.1, ENSRNOT00000166300.1

Conserved Domains (1) summary

pfam12297
Location:147 → 570

EVC2_like; Ellis van Creveld protein 2 like protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

77591581..77679286 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091722.2 → XP_038947650.1 limbin isoform X1

Related

ENSRNOP00000009914.4, ENSRNOT00000009914.8

Conserved Domains (3) summary

PTZ00121
Location:518 → 843

PTZ00121; MAEBL; Provisional

PRK12704
Location:500 → 665

PRK12704; phosphodiesterase; Provisional

pfam12297
Location:147 → 525

EVC2_like; Ellis van Creveld protein 2 like protein
XM_017599114.3 → XP_017454603.1 limbin isoform X2