Guca2a guanylate cyclase activator 2A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Guca2aprovided by RGD
Official Full Name: guanylate cyclase activator 2Aprovided by RGD
Primary source: RGD:2766
See related: EnsemblRapid:ENSRNOG00000008849 AllianceGenome:RGD:2766
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Guca2; GUANYL; Guanylin
Summary: Enables guanylate cyclase activator activity. Predicted to be located in extracellular region. Orthologous to human GUCA2A (guanylate cyclase activator 2A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 65.0), Lung (RPKM 5.9) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (138522446..138524288)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (133237177..133239019)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (138685634..138687476)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results support the hypothesis that IL-15 secreted from Gn-GC-C-expressing macrophages contributes to the inhibition of fatty acid synthase and lipid accumulation in adipocytes, leading to obesity resistance
Title: Interleukin-15 derived from Guanylin-GC-C-expressing macrophages inhibits fatty acid synthase in adipocytes.
The specific cellular distribution of both GN and UGN differs between duodenum and colon and between human and rat intestines.
Title: Cellular localization of guanylin and uroguanylin mRNAs in human and rat duodenal and colonic mucosa.
Data (including data from studies in transgenic rats) suggest guanylin--guanylyl cyclase-C signaling in macrophages in mesenteric fat regulates cGMP--PKG--VASP pathway and mesenteric panniculitis/obesity via down-regulation of proinflammatory factors.
Title: Guanylin-Guanylyl cyclase-C signaling in macrophages regulates mesenteric fat inflammation induced by high-fat diet.
the macrophagic guanylin-GC-C system contributes to the altered expression of genes involved in lipid metabolism, leading to resistance to obesity
Title: Involvement of guanylin and GC-C in rat mesenteric macrophages in resistance to a high-fat diet.
guanylin is synthesized as an intrinsic peptide in epithelial cells of the hepatobiliary system and released luminally into the hepatic and cystic bile to regulate electrolyte secretion by a paracrine/luminocrine signaling pathway
Title: Guanylin and functional coupling proteins in the hepatobiliary system of rat and guinea pig.
Guanylin plays a role in the regulation of ion transport in the colon
Title: Guanylin and E. coli heat-stable enterotoxin induce chloride secretion through direct interaction with basolateral compartment of rat and human colonic cells.
atrial natriuretic peptide, urodilatin, guanylin and uroguanylin interact in rat kidney
Title: Interaction of atrial natriuretic peptide, urodilatin, guanylin and uroguanylin in the isolated perfused rat kidney.
The early diffuse guanylin immunoreactivity we observed in ducts and acinar anlage, before the secretory set is operative, suggests guanylin has a role in cell differentiation. (Guanylin)
Title: Ontogeny of guanylin-immunoreactive cells in rat salivary glands.

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General gene information

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Markers

RH94420 (e-PCR)
- UniSTS:119668

RH142427 (e-PCR)
- UniSTS:231674

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanylate cyclase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables guanylate cyclase regulator activity	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: guanylin

Names: guanylate cyclase activator 2 (guanylin); guanylate cyclase activator 2a (guanylin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.