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    Bmper BMP-binding endothelial regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300455, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bmperprovided by RGD
    Official Full Name
    BMP-binding endothelial regulatorprovided by RGD
    Primary source
    RGD:1563373
    See related
    EnsemblRapid:ENSRNOG00000015357 AllianceGenome:RGD:1563373
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563373
    Summary
    Predicted to be involved in several processes, including blood vessel endothelial cell proliferation involved in sprouting angiogenesis; cell surface receptor protein serine/threonine kinase signaling pathway; and positive regulation of intracellular signal transduction. Predicted to act upstream of or within inner ear development and negative regulation of BMP signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in opiate dependence. Orthologous to human BMPER (BMP binding endothelial regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 45.1), Muscle (RPKM 20.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bmper in Genome Data Viewer
    Location:
    8q13
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (30008049..30253201)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (21732225..21977261)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (24369916..24615484)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480001 Neighboring gene uncharacterized LOC103693030 Neighboring gene uncharacterized LOC134480002 Neighboring gene uncharacterized LOC134479969 Neighboring gene uncharacterized LOC102556684

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis. Heinke J, et al. Circ Res, 2008 Oct 10. PMID 18787191
    2. BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation. Moser M, et al. Mol Cell Biol, 2003 Aug. PMID 12897139, Free PMC Article
    3. Bone morphogenetic protein 4 regulates microRNAs miR-494 and miR-126-5p in control of endothelial cell function in angiogenesis. Esser JS, et al. Thromb Haemost, 2017 Apr 3. PMID 28124060
    4. Substance dependence low-density whole genome association study in two distinct American populations. Yu Y, et al. Hum Genet, 2008 Jun. PMID 18438686, Free PMC Article
    5. Spatial gene expression in the T-stage mouse metanephros. Caruana G, et al. Gene Expr Patterns, 2006 Oct. PMID 16545622

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in blood vessel development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endothelial cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inner ear development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ureteric bud development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BMP-binding endothelial regulator protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135799.1 → NP_001129271.1  BMP-binding endothelial regulator protein precursor

      See identical proteins and their annotated locations for NP_001129271.1

      Status: INFERRED

      Source sequence(s)
      CH474007
      UniProtKB/TrEMBL
      A0A8I6GMI8, A6JYA2, F1M661
      Related
      ENSRNOP00000038791.5, ENSRNOT00000033460.7
      Conserved Domains (5) summary
      pfam00093
      Location:166 → 224
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:364 → 508
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:629 → 682
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:556 → 624
      C8; C8 domain
      cl17735
      Location:301 → 357
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      30008049..30253201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242715.5 → XP_006242777.1  BMP-binding endothelial regulator protein isoform X1

      Conserved Domains (5) summary
      pfam00093
      Location:87 → 145
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:285 → 429
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:550 → 603
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:477 → 545
      C8; C8 domain
      cl17735
      Location:222 → 278
      VWC; von Willebrand factor type C domain

    2. XM_039081015.2 → XP_038936943.1  BMP-binding endothelial regulator protein isoform X2

      Conserved Domains (5) summary
      pfam00093
      Location:61 → 119
      VWC; von Willebrand factor type C domain
      cl17735
      Location:196 → 252
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:259 → 403
      VWD; von Willebrand factor type D domain
      pfam08742
      Location:455 → 519
      C8; C8 domain
      cd19941
      Location:524 → 577
      TIL; trypsin inhibitor-like cysteine rich domain

    3. XM_039081016.2 → XP_038936944.1  BMP-binding endothelial regulator protein isoform X3

      Conserved Domains (4) summary
      cl17735
      Location:83 → 139
      VWC; von Willebrand factor type C domain
      pfam00094
      Location:146 → 290
      VWD; von Willebrand factor type D domain
      pfam08742
      Location:342 → 406
      C8; C8 domain
      cd19941
      Location:411 → 464
      TIL; trypsin inhibitor-like cysteine rich domain

    RNA

    1. XR_010053940.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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