Terf1 telomeric repeat binding factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Terf1provided by RGD
Official Full Name: telomeric repeat binding factor 1provided by RGD
Primary source: RGD:1311574
See related: EnsemblRapid:ENSRNOG00000007291 AllianceGenome:RGD:1311574
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including DNA binding activity; ankyrin repeat binding activity; and protein homodimerization activity. Predicted to contribute to telomerase activity. Involved in response to xenobiotic stimulus. Predicted to be located in chromosome, telomeric region; nuclear lumen; and spindle. Predicted to be part of shelterin complex. Orthologous to human TERF1 (telomeric repeat binding factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 119.4), Spleen (RPKM 81.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (8226345..8255614, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (3443103..3472377, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (2853455..2882731, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2.
Title: Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2.

Submit: New GeneRIF Correction

General gene information

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Markers

RH138681 (e-PCR)
- UniSTS:220768

RH130969 (e-PCR)
- UniSTS:214252

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding, bending	ISO Inferred from Sequence Orthology more info
enables G-rich strand telomeric DNA binding	ISO Inferred from Sequence Orthology more info
enables ankyrin repeat binding	ISO Inferred from Sequence Orthology more info
enables double-stranded telomeric DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
contributes_to telomerase activity	ISO Inferred from Sequence Orthology more info
enables telomeric DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within meiotic telomere clustering	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of establishment of RNA localization to telomere	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of establishment of protein localization to telomere	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of exonuclease activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of telomeric D-loop disassembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of shelterin complex assembly	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in telomere capping	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in telomeric D-loop disassembly	ISO Inferred from Sequence Orthology more info
NOT involved_in telomeric loop formation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
part_of nuclear telomere cap complex	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of shelterin complex	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: telomeric repeat-binding factor 1

Names: telomeric repeat binding factor (NIMA-interacting) 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012464.1 → NP_001012482.1 telomeric repeat-binding factor 1

See identical proteins and their annotated locations for NP_001012482.1

Status: PROVISIONAL

Source sequence(s)

BC089888

UniProtKB/TrEMBL

A6JFC1, F7EVI5, Q5EB98

Related

ENSRNOP00000043160.2, ENSRNOT00000049741.4

Conserved Domains (2) summary

cd11660
Location:370 → 416

SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family

cd00280
Location:63 → 251

TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

8226345..8255614 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006237729.5 → XP_006237791.1 telomeric repeat-binding factor 1 isoform X1

UniProtKB/TrEMBL

A0A8I5Y1U3

Related

ENSRNOP00000077638.1, ENSRNOT00000108921.2

Conserved Domains (3) summary

smart00717
Location:338 → 385

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11660
Location:341 → 387

SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family

cl02779
Location:63 → 222

TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...