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    Slc6a20a solute carrier family 6 member 20a [ Rattus norvegicus (Norway rat) ]

    Gene ID: 113918, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc6a20aprovided by RGD
    Official Full Name
    solute carrier family 6 member 20aprovided by RGD
    Primary source
    RGD:621651
    See related
    EnsemblRapid:ENSRNOG00000068642 AllianceGenome:RGD:621651
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Xtrp3; rB21a; Slc6a20
    Summary
    Enables L-proline transmembrane transporter activity; amino-acid betaine transmembrane transporter activity; and proline:sodium symporter activity. Involved in L-proline import across plasma membrane and amino-acid betaine transport. Predicted to be located in brush border membrane. Predicted to be active in apical plasma membrane. Orthologous to human SLC6A20 (solute carrier family 6 member 20). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 153.5), Brain (RPKM 114.9) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc6a20a in Genome Data Viewer
    Location:
    8q32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (132159768..132200016, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (123282325..123322609, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (132713013..132753145, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480118 Neighboring gene transfer RNA arginine (anticodon ACG) 2 Neighboring gene SAC1 like phosphatidylinositide phosphatase Neighboring gene solute carrier family 6 member 20b Neighboring gene leucine zipper transcription factor-like 1 Neighboring gene ribosomal biogenesis factor, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of an orphan transporter. A new member of the neurotransmitter transporter family. Smith KE, et al. FEBS Lett, 1995 Jan 2. PMID 8001687
    2. Na+-dependent and Na+-independent betaine transport across the apical membrane of rat renal epithelium. Cano M, et al. Biochim Biophys Acta, 2015 Oct. PMID 26028423
    3. Molecular cloning of the mouse IMINO system: an Na+- and Cl--dependent proline transporter. Kowalczuk S, et al. Biochem J, 2005 Mar 15. PMID 15689184, Free PMC Article
    4. Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters. Bröer S, et al. J Clin Invest, 2008 Dec. PMID 19033659, Free PMC Article
    5. SIT1 is a betaine/proline transporter that is activated in mouse eggs after fertilization and functions until the 2-cell stage. Anas MK, et al. Development, 2008 Dec. PMID 19029042

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-proline transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-proline transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-proline transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-proline transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables amino-acid betaine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neutral L-amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proline:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proline:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables proline:sodium symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proline:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proline:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables solute:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables solute:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-proline import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-proline import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-proline import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-proline import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in amino acid import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amino acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amino acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in amino-acid betaine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino-acid betaine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycine import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycine import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycine import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proline import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proline transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sodium- and chloride-dependent transporter XTRP3
    Names
    X transporter protein 3
    sodium/imino-acid transporter 1
    solute carrier family 6 (neurotransmitter transporter), member 20
    solute carrier family 6 (proline IMINO transporter), member 20
    solute carrier family 6 member 20
    transporter rB21A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133296.2 → NP_579830.2  sodium- and chloride-dependent transporter XTRP3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q64093
      UniProtKB/TrEMBL
      A6I4C2, G3V6Q4
      Related
      ENSRNOP00000007467.4, ENSRNOT00000007467.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      132159768..132200016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264728.1 → XP_063120798.1  sodium- and chloride-dependent transporter XTRP3 isoform X3

    2. XM_039080653.2 → XP_038936581.1  sodium- and chloride-dependent transporter XTRP3 isoform X3

      Conserved Domains (1) summary
      cl00456
      Location:26 → 336
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. XM_063264726.1 → XP_063120796.1  sodium- and chloride-dependent transporter XTRP3 isoform X2

    4. XM_063264729.1 → XP_063120799.1  sodium- and chloride-dependent transporter XTRP3 isoform X3

    5. XM_063264725.1 → XP_063120795.1  sodium- and chloride-dependent transporter XTRP3 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64093.1 GenPept UniProtKB/Swiss-Prot:Q64093

    Gene LinkOut

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