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    Gspt1 G1 to S phase transition 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24420, updated on 9-Dec-2024

    Summary

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    Symbol
    Gspt1provided by RGD
    Full Name
    G1 to S phase transition 1provided by RGD
    Primary source
    RGD:2751
    See related
    EnsemblRapid:ENSRNOG00000046271 AllianceGenome:RGD:2751
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activity and translation release factor activity. Predicted to be involved in regulation of translational termination and translational termination. Predicted to act upstream of or within protein methylation. Predicted to be part of translation release factor complex. Predicted to be active in cytosolic ribosome. Orthologous to human GSPT1 (G1 to S phase transition 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 355.4), Adrenal (RPKM 354.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gspt1 in Genome Data Viewer
    Location:
    10q11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (4867687..4904186)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (4362528..4397215)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (4313100..4347661)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene sorting nexin 29 Neighboring gene uncharacterized LOC134480744 Neighboring gene TNF receptor superfamily member 17 Neighboring gene uncharacterized LOC120095016 Neighboring gene uncharacterized LOC100911627 Neighboring gene ribosomal L1 domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. [Human transmissible dementia: prion diseases?]. Dreux C, et al. Bull Acad Natl Med, 1992 Nov. PMID 1300226
    2. The effect of eukaryotic release factor depletion on translation termination in human cell lines. Janzen DM, et al. Nucleic Acids Res, 2004. PMID 15326224, Free PMC Article
    3. Regulation of HIV-1 Gag-Pol Expression by Shiftless, an Inhibitor of Programmed -1 Ribosomal Frameshifting. Wang X, et al. Cell, 2019 Jan 24. PMID 30682371, Free PMC Article
    4. Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1. Hoshino S, et al. J Biol Chem, 1998 Aug 28. PMID 9712840
    5. The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein. Hegde R, et al. J Biol Chem, 2003 Oct 3. PMID 12865429

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94063

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation release factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation release factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translational termination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational termination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of translation release factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of translation release factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic peptide chain release factor GTP-binding subunit ERF3A
    Names
    G1 to S phase transition protein 1
    G1 to phase transition 1
    eukaryotic peptide chain release factor GTP-binding subunit ERF3B-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003978.2 → NP_001003978.1  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 1

      See identical proteins and their annotated locations for NP_001003978.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      F7F6J0, M0RC00, Q6AYD5
      Related
      ENSRNOP00000067103.1, ENSRNOT00000074487.4
      Conserved Domains (5) summary
      cd01883
      Location:213 → 429
      EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
      COG5256
      Location:209 → 633
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
      pfam07145
      Location:62 → 79
      PAM2; Ataxin-2 C-terminal region
      cd04089
      Location:438 → 519
      eRF3_II; Domain II of the eukaryotic class II release factor
      cd03704
      Location:525 → 631
      eRF3_C_III; C-terminal domain of eRF3

    2. NM_001429887.1 → NP_001416816.1  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      F7F6J0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      4867687..4904186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017596996.3 → XP_017452485.1  eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1

      Conserved Domains (5) summary
      cd01883
      Location:212 → 428
      EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
      COG5256
      Location:208 → 632
      TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
      pfam07145
      Location:62 → 79
      PAM2; Ataxin-2 C-terminal region
      cd04089
      Location:437 → 518
      eRF3_II; Domain II of the eukaryotic class II release factor
      cd03704
      Location:524 → 630
      eRF3_C_III; C-terminal domain of eRF3
    Nucleotide Protein Strain
    Heading Accession and Version

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