Prep prolyl endopeptidase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prepprovided by RGD
Official Full Name: prolyl endopeptidaseprovided by RGD
Primary source: RGD:620841
See related: EnsemblRapid:ENSRNOG00000051061 AllianceGenome:RGD:620841
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: rPop
Summary: Enables endopeptidase activity and peptide binding activity. Involved in protein catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Biomarker of depressive disorder. Orthologous to human PREP (prolyl endopeptidase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 107.1), Kidney (RPKM 96.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q13

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (50138588..50235549)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (48556211..48653165)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (50172618..50269992)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of Prolyl Oligopeptidase Restores Prohibitin 2 Levels in Psychosis Models: Relationship to Cognitive Deficits in Schizophrenia.
Title: Inhibition of Prolyl Oligopeptidase Restores Prohibitin 2 Levels in Psychosis Models: Relationship to Cognitive Deficits in Schizophrenia.
Long-Term Social Isolation Reduces Expression of the BDNF Precursor and Prolyl Endopeptidase in the Rat Brain.
Title: Long-Term Social Isolation Reduces Expression of the BDNF Precursor and Prolyl Endopeptidase in the Rat Brain.
In mitotic phases, PREP shares its localization with tubulin in Sertoli cells, gonocytes, and spermatogonia.
Title: Subcellular Localization of Prolyl Endopeptidase During the First Wave of Rat Spermatogenesis and in Rat and Human Sperm.
The data indicated the involvement of genes associated with the serotoninergic system in the mechanisms of mental disorders induced by post-weaning social isolation and suggest the gene encoding prolyl endopeptidase as a candidate gene involved in the pathogenesis of these disorders.
Title: Post-Weaning Social Isolation Disturbs Gene Expression in Rat Brain Structures.
Frontal cortex prolyl endopeptidase levels are reduced following benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine treatment in a rat model of depressive syndrome.
Title: Effect of prolyl endopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine on activity of proline-specific peptidases in brain structures of rats with experimental MPTP-induced depressive syndrome.
PREP is not significantly responsible for the in vivo extracellular space cleavage of substance P or neurotensin.
Title: Inhibition of prolyl oligopeptidase by KYP-2047 fails to increase the extracellular neurotensin and substance P levels in rat striatum.
Data show that enzymatic activity of prolyl oligopeptidase (POP) is highest on embryonic day 18 while the protein amounts reach their peak at birth, and support a role for POP in neurogenesis.
Title: Sequential expression, activity and nuclear localization of prolyl oligopeptidase protein in the developing rat brain.
Overall, the present data support the possibility that PEP exerts specific functions related to neurodevelopment besides those proposed to date.
Title: Prolyl endopeptidase mRNA expression in the central nervous system during rat development.
localization of POP in thalamocortical & corticothalamic projection neurons in ventrobasal complex & medial geniculate nucleus of thalamus & somatosensory/motor & auditory cortices; in thalamus & cortex over 50% of projection neurons contained POP
Title: Localization of prolyl oligopeptidase in the thalamic and cortical projection neurons: a retrograde neurotracing study in the rat brain.
Results describe the distribution of immunoreactive prolyl oligopeptidase in human and rat brain.
Title: Distribution of immunoreactive prolyl oligopeptidase in human and rat brain.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables oligopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide binding	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prolyl endopeptidase

Names: PE; post-proline cleaving enzyme

NP_112614.2

EC 3.4.21.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031324.2 → NP_112614.2 prolyl endopeptidase

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

O70196

UniProtKB/TrEMBL

A0A0G2K1M8, A6K6V5

Related

ENSRNOP00000110849.1, ENSRNOT00000160646.1

Conserved Domains (1) summary

COG1505
Location:26 → 704

PreP; Prolyl oligopeptidase PreP, S9A serine peptidase family [Amino acid transport and metabolism]