Mme membrane metallo-endopeptidase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mmeprovided by RGD
Official Full Name: membrane metallo-endopeptidaseprovided by RGD
Primary source: RGD:3098
See related: EnsemblRapid:ENSRNOG00000009514 AllianceGenome:RGD:3098
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nep; SFE; CD10
Summary: Enables oligopeptidase activity and peptide binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; placenta development; and response to estrogen. Predicted to be located in several cellular components, including brush border; cytoplasmic vesicle; and trans-Golgi network. Predicted to be active in plasma membrane. Used to study diarrhea and hypertension. Biomarker of Alzheimer's disease; congestive heart failure; and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Alzheimer's disease; Charcot-Marie-Tooth disease axonal type 2T; cerebellar ataxia type 43; cerebral amyloid angiopathy; and membranous glomerulonephritis. Orthologous to human MME (membrane metalloendopeptidase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 654.8), Adrenal (RPKM 182.2) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q31

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (149806826..149957381)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (147686913..147803808)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (153799203..153880910)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Caspase Inhibition Restores NEP Expression and Rescues Olfactory Deficit in Rats Caused by Prenatal Hypoxia.
Title: Caspase Inhibition Restores NEP Expression and Rescues Olfactory Deficit in Rats Caused by Prenatal Hypoxia.
Developmental Profile of Brain Neprilysin Expression Correlates with Olfactory Behaviour of Rats.
Title: Developmental Profile of Brain Neprilysin Expression Correlates with Olfactory Behaviour of Rats.
Study shows that chronic intermittent hypoxia (CIH) induces changes on the expression and activity of neprilysin (NEP) in the brain of rats. Data show that CIH protocol increases the expression and activity of NEP selectively in the temporal cortex.
Title: Chronic intermittent hypoxia induces changes on the expression and activity of neprilysin (EC 3.4.24.11) in the brain of rats.
In standard light/dark conditions, the results demonstrated an opposite daily rhythm in hypothalamus and pituitary. While the highest levels of AlaAP or enkephalinase activities were measured in hypothalamus during the dark period, they were the highest in the pituitary during the light one.
Title: Light-dark influence on enkephalinase activity in hypothalamus and pituitary.
hypoxia increased the expression of platelet-derived growth factor (PDGF) and transforming growth factor-beta1 (TGF-beta1) and decreased the expression of neprilysin (NEP), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells.
Title: The role of PDGF-B/TGF-β1/neprilysin network in regulating endothelial-to-mesenchymal transition in pulmonary artery remodeling.
The data obtained suggest that the increase of caspase-3 enzyme activity could affect NEP expression via proteolytic degradation of its transcription factor AICD
Title: [ROLE OF CASPASE-3 IN REGULATION OF THE CONTENT OF THE AMYLOID-DEGRADING NEUROPEPTIDASE NEPRILYSIN IN THE CORTEX OF RATS AFTER HYPOXIA].
the increased expression of NPR-C (r=-0.943 and -0.837 for mRNA and protein respectively, p<0.05) and NEP (r=-0.687 and -0.823 for mRNA and protein respectively, p<0.05) were accompanied by a signi fi cant decline in CNP.
Title: Paradoxical expressions of natriuretic peptide receptor-C and neutral endopeptidase account for C-type natriuretic peptide decline during the progression of experimental obstructive nephropathy.
Data suggest that the brain expression of neprilysin may promote amyloid beta-protein (Abeta)deposition in patients with Alzheimer's disease (AD).
Title: Leptin inhibits amyloid β-protein degradation through decrease of neprilysin expression in primary cultured astrocytes.
These results suggested that ketamine suppresses the Abeta degradation of NEP by reducing p38 MAPK-mediated pathway activity.
Title: Ketamine reduces amyloid β-protein degradation by suppressing neprilysin expression in primary cultured astrocytes.
Naoerkang can increase the expression of NEP in hippocampal tissues of AD rats so as to reduce the quantity of AAbeta(1-42).
Title: [Effects of Naoerkang on expressions of beta-amyloid peptide 1-42 and neprilysin in hippocampus in a rat model of Alzheimer's disease].

Submit: New GeneRIF Correction See all GeneRIFs (24)

General gene information

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Markers

Mme (e-PCR), detects polymorphism
- UniSTS:143877

RH132069 (e-PCR)
- UniSTS:215352

D2Mco32 (e-PCR)
- UniSTS:239450

D2Mco33 (e-PCR)
- UniSTS:239451

RH94409 (e-PCR)
- UniSTS:119657

39.MHAa90d3.seq (e-PCR)
- UniSTS:159122

D2Wox43 (e-PCR)
- UniSTS:240040

RH140580 (e-PCR)
- UniSTS:222649

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cardiolipin binding	IEA Inferred from Electronic Annotation more info
enables cardiolipin binding	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables exopeptidase activity	IEA Inferred from Electronic Annotation more info
enables exopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables oligopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables peptide binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylserine binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in amyloid-beta clearance	IBA Inferred from Biological aspect of Ancestor more info
involved_in amyloid-beta clearance	IDA Inferred from Direct Assay more info	PubMed
involved_in amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
involved_in amyloid-beta clearance by cellular catabolic process	IEA Inferred from Electronic Annotation more info
involved_in amyloid-beta clearance by cellular catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amyloid-beta clearance by cellular catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within amyloid-beta metabolic process	ISO Inferred from Sequence Orthology more info
involved_in amyloid-beta metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in bradykinin catabolic process	IEA Inferred from Electronic Annotation more info
involved_in bradykinin catabolic process	ISO Inferred from Sequence Orthology more info
involved_in bradykinin catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to UV-A	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV-A	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV-A	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to UV-B	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV-B	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV-B	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to cytokine stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cytokine stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in creatinine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in creatinine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in creatinine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in hormone catabolic process	IEA Inferred from Electronic Annotation more info
involved_in hormone catabolic process	ISO Inferred from Sequence Orthology more info
involved_in hormone catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in kidney development	IEA Inferred from Electronic Annotation more info
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in kidney development	ISO Inferred from Sequence Orthology more info
involved_in kidney development	ISS Inferred from Sequence or Structural Similarity more info
involved_in learning or memory	IEA Inferred from Electronic Annotation more info
involved_in learning or memory	ISO Inferred from Sequence Orthology more info
involved_in lung development	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuropeptide processing	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide processing	ISO Inferred from Sequence Orthology more info
involved_in peptide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in placenta development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in replicative senescence	IEA Inferred from Electronic Annotation more info
involved_in replicative senescence	ISO Inferred from Sequence Orthology more info
involved_in replicative senescence	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estrogen	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory perception of pain	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of pain	ISS Inferred from Sequence or Structural Similarity more info
involved_in substance P catabolic process	IEA Inferred from Electronic Annotation more info
involved_in substance P catabolic process	ISO Inferred from Sequence Orthology more info
involved_in substance P catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in brush border	IEA Inferred from Electronic Annotation more info
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in brush border	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in neuron projection terminus	IEA Inferred from Electronic Annotation more info
located_in neuron projection terminus	ISO Inferred from Sequence Orthology more info
located_in neuron projection terminus	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in presynapse	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptic vesicle	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neprilysin

Names: atriopeptidase; enkephalinase; membrane metallo-endopeptidase (neutral endopeptidase/enkephalinase); neutral endopeptidase 24.11; skin fibroblast elastase

NP_036740.1

EC 3.4.24.11

XP_038957646.1

EC 3.4.24.11

XP_038957647.1

EC 3.4.24.11

XP_038957648.1

EC 3.4.24.11

XP_063137363.1

EC 3.4.24.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012608.2 → NP_036740.1 neprilysin

See identical proteins and their annotated locations for NP_036740.1

Status: PROVISIONAL

Source sequence(s)

BC085753

UniProtKB/Swiss-Prot

P07861

UniProtKB/TrEMBL

A0A0H2UHX5, A6JVN6

Related

ENSRNOP00000044578.5, ENSRNOT00000042576.6

Conserved Domains (1) summary

cd08662
Location:79 → 748

M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

149806826..149957381

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101719.2 → XP_038957647.1 neprilysin isoform X1

UniProtKB/Swiss-Prot

P07861

UniProtKB/TrEMBL

A0A0H2UHX5, A6JVN6

Conserved Domains (1) summary

cd08662
Location:79 → 748

M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I
XM_039101718.2 → XP_038957646.1 neprilysin isoform X1

UniProtKB/Swiss-Prot

P07861

UniProtKB/TrEMBL

A0A0H2UHX5, A6JVN6

Conserved Domains (1) summary

cd08662
Location:79 → 748

M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I
XM_063281293.1 → XP_063137363.1 neprilysin isoform X1

UniProtKB/Swiss-Prot

P07861

UniProtKB/TrEMBL

A0A0H2UHX5, A6JVN6
XM_039101720.2 → XP_038957648.1 neprilysin isoform X2

UniProtKB/TrEMBL

A0A0H2UHX5

Conserved Domains (1) summary

cd08662
Location:79 → 660

M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I