Gpr173 G-protein coupled receptor 173 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Gpr173provided by RGD
Full Name: G-protein coupled receptor 173provided by RGD
Primary source: RGD:620748
See related: EnsemblRapid:ENSRNOG00000060137 AllianceGenome:RGD:620748
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sreb3
Summary: Predicted to enable gonadotropin-releasing hormone receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cellular response to gonadotropin-releasing hormone. Predicted to act upstream of or within negative regulation of neuron migration. Predicted to be active in plasma membrane. Orthologous to human GPR173 (G protein-coupled receptor 173). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: Xq13

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (24925634..24950485, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (21446261..21471119, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (22417753..22418873, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Levels of the neuropeptide phoenixin-14 and its receptor GRP173 in the hypothalamus, ovary and periovarian adipose tissue in rat model of polycystic ovary syndrome.
Title: Levels of the neuropeptide phoenixin-14 and its receptor GRP173 in the hypothalamus, ovary and periovarian adipose tissue in rat model of polycystic ovary syndrome.
These studies are the first to demonstrate a functional relationship between PNX and Gpr173 in reproductive physiology and identify a potential therapeutic target for ovulatory dysfunction.
Title: Hypothalamic action of phoenixin to control reproductive hormone secretion in females: importance of the orphan G protein-coupled receptor Gpr173.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables gonadotropin-releasing hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables gonadotropin-releasing hormone receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to gonadotropin-releasing hormone	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of neuron migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: probable G-protein coupled receptor 173

Names: probable G-protein coupled receptor 173-like; super conserved receptor expressed in brain 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022255.3 → NP_071591.1 probable G-protein coupled receptor 173

See identical proteins and their annotated locations for NP_071591.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q9JJH2

UniProtKB/TrEMBL

A0A8I6AH63, A6KLC3

Related

ENSRNOP00000092248.2, ENSRNOT00000088630.3

Conserved Domains (2) summary

cd14964
Location:24 → 50

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:23 → 351

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily