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    Camk1d calcium/calmodulin-dependent protein kinase ID [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307124, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Camk1dprovided by RGD
    Official Full Name
    calcium/calmodulin-dependent protein kinase IDprovided by RGD
    Primary source
    RGD:1560691
    See related
    EnsemblRapid:ENSRNOG00000017882 AllianceGenome:RGD:1560691
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560691
    Summary
    Predicted to enable calcium/calmodulin-dependent protein kinase activity and calmodulin binding activity. Predicted to be involved in several processes, including positive regulation of CREB transcription factor activity; positive regulation of neutrophil chemotaxis; and regulation of neuron projection development. Predicted to act upstream of or within negative regulation of apoptotic process and positive regulation of apoptotic process. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human CAMK1D (calcium/calmodulin dependent protein kinase ID). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 69.1), Thymus (RPKM 54.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Camk1d in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (77491191..77892018)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (72581899..72982704)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (76532611..76938956)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551026 Neighboring gene uncharacterized LOC102551092 Neighboring gene uncharacterized LOC108348589 Neighboring gene coiled-coil domain containing 3 Neighboring gene uncharacterized LOC108348590

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function. Verploegen S, et al. Blood, 2005 Aug 1. PMID 15840691
    2. Effects of PU.1-induced mouse calcium-calmodulin-dependent kinase I-like kinase (CKLiK) on apoptosis of murine erythroleukemia cells. Yamada T, et al. Exp Cell Res, 2004 Mar 10. PMID 14980499
    3. Identification and characterization of CKLiK, a novel granulocyte Ca(++)/calmodulin-dependent kinase. Verploegen S, et al. Blood, 2000 Nov 1. PMID 11050006
    4. A cascade of Ca(2+)/calmodulin-dependent protein kinases regulates the differentiation and functional activation of murine neutrophils. Gaines P, et al. Exp Hematol, 2008 Jul. PMID 18400360, Free PMC Article
    5. Prominent expression and activity-dependent nuclear translocation of Ca2+/calmodulin-dependent protein kinase Idelta in hippocampal neurons. Sakagami H, et al. Eur J Neurosci, 2005 Dec. PMID 16324104

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of CREB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of respiratory burst ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of granulocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calcium/calmodulin-dependent protein kinase type 1D
    NP_001100835.1
    XP_038951705.1
    XP_038951706.1
    XP_038951707.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107365.2 → NP_001100835.1  calcium/calmodulin-dependent protein kinase type 1D isoform 1

      See identical proteins and their annotated locations for NP_001100835.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6AUH0, A6JLY7, F1LVR4
      Related
      ENSRNOP00000095984.1, ENSRNOT00000105055.2
      Conserved Domains (1) summary
      cd14168
      Location:12 → 312
      STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta

    2. NM_001433924.1 → NP_001420853.1  calcium/calmodulin-dependent protein kinase type 1D isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      F1LVR4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      77491191..77892018
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095777.2 → XP_038951705.1  calcium/calmodulin-dependent protein kinase type 1D isoform X1

      UniProtKB/TrEMBL
      F1LVR4
      Related
      ENSRNOP00000024099.7, ENSRNOT00000024099.8
      Conserved Domains (1) summary
      cd14168
      Location:12 → 312
      STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta

    2. XM_039095778.2 → XP_038951706.1  calcium/calmodulin-dependent protein kinase type 1D isoform X2

      Conserved Domains (1) summary
      cd14168
      Location:12 → 312
      STKc_CaMKI_delta; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta

    3. XM_039095779.2 → XP_038951707.1  calcium/calmodulin-dependent protein kinase type 1D isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:1 → 215
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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