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    Plgrkt plasminogen receptor with a C-terminal lysine [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293888, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plgrktprovided by RGD
    Official Full Name
    plasminogen receptor with a C-terminal lysineprovided by RGD
    Primary source
    RGD:1306839
    See related
    EnsemblRapid:ENSRNOG00000015932 AllianceGenome:RGD:1306839
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Plg-R(KT); RGD1306839
    Summary
    Predicted to be involved in positive regulation of plasminogen activation. Predicted to be located in mitochondrion and plasma membrane. Orthologous to human PLGRKT (plasminogen receptor with a C-terminal lysine). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 42.2), Kidney (RPKM 39.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plgrkt in Genome Data Viewer
    Location:
    1q52
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (236512574..236526858, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (227099005..227111277, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (247502274..247514540, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene prohibitin 1, pseudogene 9 Neighboring gene relaxin 1 Neighboring gene CD274 molecule Neighboring gene nucleolar pre-rRNA processing protein NIP7, pseudogene 2 Neighboring gene uncharacterized LOC134485219 Neighboring gene programmed cell death 1 ligand 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Proteomics-based discovery of a novel, structurally unique, and developmentally regulated plasminogen receptor, Plg-RKT, a major regulator of cell surface plasminogen activation. Andronicos NM, et al. Blood, 2010 Feb 18. PMID 19897580, Free PMC Article
    2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of plasminogen activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of plasminogen activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    plasminogen receptor (KT)
    Names
    plasminogen receptor, C-terminal lysine transmembrane protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106347.1 → NP_001099817.1  plasminogen receptor (KT)

      See identical proteins and their annotated locations for NP_001099817.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/Swiss-Prot
      D4ACN8
      Related
      ENSRNOP00000021545.4, ENSRNOT00000021544.7
      Conserved Domains (1) summary
      pfam10166
      Location:1 → 134
      DUF2368; Uncharacterized conserved protein (DUF2368)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      236512574..236526858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287022.1 → XP_063143092.1  plasminogen receptor (KT) isoform X1

      UniProtKB/Swiss-Prot
      D4ACN8

    2. XM_039108851.2 → XP_038964779.1  plasminogen receptor (KT) isoform X1

      UniProtKB/Swiss-Prot
      D4ACN8
      Conserved Domains (1) summary
      pfam10166
      Location:1 → 134
      DUF2368; Uncharacterized conserved protein (DUF2368)

    3. XM_006231203.5 → XP_006231265.1  plasminogen receptor (KT) isoform X1

      See identical proteins and their annotated locations for XP_006231265.1

      UniProtKB/Swiss-Prot
      D4ACN8
      Conserved Domains (1) summary
      pfam10166
      Location:1 → 134
      DUF2368; Uncharacterized conserved protein (DUF2368)

    4. XM_039108861.2 → XP_038964789.1  plasminogen receptor (KT) isoform X1

      UniProtKB/Swiss-Prot
      D4ACN8
      Conserved Domains (1) summary
      pfam10166
      Location:1 → 134
      DUF2368; Uncharacterized conserved protein (DUF2368)

    5. XM_006231205.4 → XP_006231267.1  plasminogen receptor (KT) isoform X1

      See identical proteins and their annotated locations for XP_006231267.1

      UniProtKB/Swiss-Prot
      D4ACN8
      Conserved Domains (1) summary
      pfam10166
      Location:1 → 134
      DUF2368; Uncharacterized conserved protein (DUF2368)

    6. XM_039108864.2 → XP_038964792.1  plasminogen receptor (KT) isoform X1

      UniProtKB/Swiss-Prot
      D4ACN8
      Conserved Domains (1) summary
      pfam10166
      Location:1 → 134
      DUF2368; Uncharacterized conserved protein (DUF2368)

    7. XM_039108853.2 → XP_038964781.1  plasminogen receptor (KT) isoform X1

      UniProtKB/Swiss-Prot
      D4ACN8
      Conserved Domains (1) summary
      pfam10166
      Location:1 → 134
      DUF2368; Uncharacterized conserved protein (DUF2368)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D4ACN8.1 GenPept UniProtKB/Swiss-Prot:D4ACN8

    Gene LinkOut

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