Lamc3 laminin subunit gamma 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Lamc3provided by RGD
Full Name: laminin subunit gamma 3provided by RGD
Primary source: RGD:1309399
See related: EnsemblRapid:ENSRNOG00000059507 AllianceGenome:RGD:1309399
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to act upstream of or within several processes, including astrocyte development; retina development in camera-type eye; and visual perception. Predicted to be located in basement membrane. Orthologous to human LAMC3 (laminin subunit gamma 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 115.2), Uterus (RPKM 69.9) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (35562989..35624460)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (15165220..15226697)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (9265407..9327107, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a complex of laminin alpha 3, beta3 and gamma3 chains serves as the ligand for alpha 6beta1-integrin at the apical ectoplasmic specialization in adult rat testes
Title: Laminin alpha 3 forms a complex with beta3 and gamma3 chains that serves as the ligand for alpha 6beta1-integrin at the apical ectoplasmic specialization in adult rat testes.

Submit: New GeneRIF Correction

General gene information

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Markers

RH144007 (e-PCR)
- UniSTS:233253

RH132596 (e-PCR)
- UniSTS:215879

RH133133 (e-PCR)
- UniSTS:216416

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within astrocyte development	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within visual perception	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: laminin subunit gamma-3

Names: laminin gamma 3; laminin subunit gamma-3-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107830.1 → NP_001101300.1 laminin subunit gamma-3 precursor

See identical proteins and their annotated locations for NP_001101300.1

Status: PROVISIONAL

Source sequence(s)

CH474001

UniProtKB/TrEMBL

A0A0G2K023, A6JU33

Related

ENSRNOP00000101734.1, ENSRNOT00000133977.1

Conserved Domains (8) summary

cd00055
Location:718 → 765

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00052
Location:550 → 671

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:928 → 976

Laminin_EGF; Laminin EGF domain

pfam00055
Location:53 → 278

Laminin_N; Laminin N-terminal (Domain VI)

pfam06008
Location:1183 → 1464

Laminin_I; Laminin Domain I

pfam14662
Location:1387 → 1574

KASH_CCD; Coiled-coil region of CCDC155 or KASH

cl02488
Location:1407 → 1572

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl21478
Location:1211 → 1308

ATP-synt_B; ATP synthase B/B' CF(0)