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    Ccn6 cellular communication network factor 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499461, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccn6provided by RGD
    Official Full Name
    cellular communication network factor 6provided by RGD
    Primary source
    RGD:1564120
    See related
    EnsemblRapid:ENSRNOG00000000597 AllianceGenome:RGD:1564120
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wisp3; RGD1564120
    Summary
    Predicted to enable heparin binding activity and integrin binding activity. Predicted to be involved in several processes, including positive regulation of cell differentiation; regulation of mitochondrial membrane potential; and regulation of reactive oxygen species biosynthetic process. Predicted to act upstream of or within negative regulation of angiogenesis and negative regulation of cell population proliferation. Predicted to be located in mitochondrion. Predicted to be active in extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in arthropathy and progressive pseudorheumatoid arthropathy of childhood. Orthologous to human CCN6 (cellular communication network factor 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 53.2), Spleen (RPKM 12.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccn6 in Genome Data Viewer
    Location:
    20q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (44123932..44139745, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (42569309..42585126, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (44237491..44255064, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene laminin subunit alpha 4 Neighboring gene uncharacterized LOC120098941 Neighboring gene family with sequence similarity 229, member B Neighboring gene tubulin, epsilon 1 Neighboring gene uncharacterized LOC108349081 Neighboring gene claudin-7 pseudogene Neighboring gene FYN proto-oncogene, Src family tyrosine kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. WISP3 prevents fibroblast-myofibroblast transdifferentiation in NRK-49F cells. Yi Y, et al. Biomed Pharmacother, 2018 Mar. PMID 29353205
    2. CCN6 regulates mitochondrial function. Patra M, et al. J Cell Sci, 2016 Jul 15. PMID 27252383
    3. WISP3 is a novel tumor suppressor gene of inflammatory breast cancer. Kleer CG, et al. Oncogene, 2002 May 9. PMID 12082632
    4. Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia. Hurvitz JR, et al. Nat Genet, 1999 Sep. PMID 10471507
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WISP3 was an anti-fibrotic factor in fibroblast-myofibroblast transdifferentiation.
      Title: WISP3 prevents fibroblast-myofibroblast transdifferentiation in NRK-49F cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cellular communication network factor 6
    Names
    WNT1 inducible signaling pathway protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170483.1 → NP_001163954.1  cellular communication network factor 6 precursor

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      D3ZDL5
      Related
      ENSRNOP00000000735.5, ENSRNOT00000000735.7
      Conserved Domains (2) summary
      pfam00219
      Location:48 → 100
      IGFBP; Insulin-like growth factor binding protein
      cl21545
      Location:275 → 342
      GHB_like; Glycoprotein hormone beta chain homologues

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      44123932..44139745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099026.2 → XP_038954954.1  cellular communication network factor 6 isoform X1

      Conserved Domains (2) summary
      pfam19035
      Location:132 → 175
      TSP1_CCN; CCN3 Nov like TSP1 domain
      cl21545
      Location:198 → 265
      GHB_like; Glycoprotein hormone beta chain homologues
    Nucleotide Protein Strain
    Heading Accession and Version

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