Fus Fus RNA binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fusprovided by RGD
Official Full Name: Fus RNA binding proteinprovided by RGD
Primary source: RGD:1308864
See related: EnsemblRapid:ENSRNOG00000023360 AllianceGenome:RGD:1308864
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables ionotropic glutamate receptor binding activity; myosin V binding activity; and nuclear receptor binding activity. Involved in cellular response to calcium ion. Located in dendritic spine head; perikaryon; and perinuclear region of cytoplasm. Is active in glutamatergic synapse and presynaptic cytosol. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 6; essential tremor 4; liposarcoma; and neurodegenerative disease. Orthologous to human FUS (FUS RNA binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 176.1), Lung (RPKM 128.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q37

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (192007011..192020887)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (182576479..182590417)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (199412805..199426705)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circular RNA SLC8A1 triggers hippocampal neuronal ferroptosis by regulating FUS-mediated ATF3 mRNA stability in epilepsy.
Title: Circular RNA SLC8A1 triggers hippocampal neuronal ferroptosis by regulating FUS-mediated ATF3 mRNA stability in epilepsy.
Identification of a novel interaction of FUS and syntaphilin may explain synaptic and mitochondrial abnormalities caused by ALS mutations.
Title: Identification of a novel interaction of FUS and syntaphilin may explain synaptic and mitochondrial abnormalities caused by ALS mutations.
Sp1-induced LncRNA CTBP1-AS2 is a novel regulator in cardiomyocyte hypertrophy by interacting with FUS to stabilize TLR4.
Title: Sp1-induced LncRNA CTBP1-AS2 is a novel regulator in cardiomyocyte hypertrophy by interacting with FUS to stabilize TLR4.
FUS could cause sleep-wake and circadian disturbance as early symptoms in cognitive deficits.
Title: Sleep and circadian abnormalities precede cognitive deficits in R521C FUS knockin rats.
Tau mRNA is identified as a physiological splicing target of FUS.
Title: Loss of fused in sarcoma (FUS) promotes pathological Tau splicing.
Findings suggest that TDP-43 and FUS play an important role in development and that constant and robust expression of the genes in motor neurons may render the neurons vulnerable to pathogenic mutation of the TDP-43 or the FUS gene.
Title: Sustained expression of TDP-43 and FUS in motor neurons in rodent's lifetime.
results suggested that TLS (FUS) might be involved in a calcium-dependent trafficking of specific NR1 splice variants in retinal ganglion cells
Title: TLS interaction with NMDA R1 splice variant in retinal ganglion cell line RGC-5.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fus (e-PCR), detects polymorphism
- UniSTS:479000

RH137118 (e-PCR)
- UniSTS:219206

RH130052 (e-PCR)
- UniSTS:213340

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ionotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA 3'-UTR binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables myosin V binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear estrogen receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear retinoid X receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear thyroid hormone receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mRNA stabilization	ISO Inferred from Sequence Orthology more info
involved_in membraneless organelle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine head	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membraneless organelle	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic cytosol	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RNA-binding protein FUS

Names: 16) in malignant liposarcoma); 16) malignant liposarcoma; fused in sarcoma RNA binding protein; fusion (involved in t(12; fusion, derived from t(12; fusion, derived from t(12;16) malignant liposarcoma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012137.1 → NP_001012137.1 RNA-binding protein FUS

See identical proteins and their annotated locations for NP_001012137.1

Status: PROVISIONAL

Source sequence(s)

BC087153

UniProtKB/TrEMBL

A6I9X8, F7FDP3, Q5PQK2

Related

ENSRNOP00000111086.1, ENSRNOT00000132026.1

Conserved Domains (4) summary

COG0724
Location:257 → 367

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12535
Location:276 → 361

RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins

sd00029
Location:419 → 440

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam00641
Location:415 → 442

zf-RanBP; Zn-finger in Ran binding protein and others

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

192007011..192020887

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230290.5 → XP_006230352.1 RNA-binding protein FUS isoform X1

UniProtKB/TrEMBL

A6I9X8

Conserved Domains (4) summary

COG0724
Location:256 → 366

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12535
Location:275 → 360

RRM_FUS_TAF15; RNA recognition motif in vertebrate fused in Ewing's sarcoma protein (FUS), TATA-binding protein-associated factor 15 (TAF15) and similar proteins

sd00029
Location:418 → 439

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam00641
Location:414 → 441

zf-RanBP; Zn-finger in Ran binding protein and others
XM_063265634.1 → XP_063121704.1 RNA-binding protein FUS isoform X2