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    Cpamd8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297572, updated on 9-Dec-2024

    Summary

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    Symbol
    Cpamd8provided by RGD
    Full Name
    C3 and PZP-like, alpha-2-macroglobulin domain containing 8provided by RGD
    Primary source
    RGD:1566313
    See related
    EnsemblRapid:ENSRNOG00000065350 AllianceGenome:RGD:1566313
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566313
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in eye development. Predicted to be located in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 5795.8) See more
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    Genomic context

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    See Cpamd8 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (157004905..157085187, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (155332827..155413098, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (154780044..154997086, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350756 Neighboring gene murinoglobulin 2 Neighboring gene thymosin beta-10-like Neighboring gene uncharacterized LOC134486841 Neighboring gene killer cell lectin like receptor G1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and sequencing of cDNA clones for the rodent negative acute-phase protein alpha 1-inhibitor 3. Schweizer M, et al. Eur J Biochem, 1987 Apr 15. PMID 2436907

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protease binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in eye development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    C3 and PZP-like, alpha-2-macroglobulin domain containing 8
    Names
    alpha-1-inhibitor 3-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271376.1 → NP_001258305.1  C3 and PZP-like, alpha-2-macroglobulin domain containing 8 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6AG69
      Conserved Domains (7) summary
      COG2373
      Location:94 → 1066
      YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
      cd02897
      Location:969 → 1275
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:749 → 839
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:129 → 221
      A2M_N; MG2 domain
      pfam07677
      Location:1387 → 1474
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1022 → 1277
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:459 → 606
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      157004905..157085187 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285903.1 → XP_063141973.1  C3 and PZP-like, alpha-2-macroglobulin domain containing 8 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AG69

    2. XM_063285902.1 → XP_063141972.1  C3 and PZP-like, alpha-2-macroglobulin domain containing 8 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AG69

    3. XM_039107442.2 → XP_038963370.1  C3 and PZP-like, alpha-2-macroglobulin domain containing 8 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AG69, A0A8I6AMC9
      Related
      ENSRNOP00000090116.1, ENSRNOT00000096100.2
      Conserved Domains (7) summary
      cd02897
      Location:969 → 1276
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:749 → 839
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:129 → 221
      A2M_N; MG2 domain
      pfam07677
      Location:1388 → 1475
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:457 → 607
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam17789
      Location:348 → 443
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:223 → 309
      MG3; Macroglobulin domain MG3

    4. XM_039107440.2 → XP_038963368.1  C3 and PZP-like, alpha-2-macroglobulin domain containing 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AG69
      Related
      ENSRNOP00000093647.1, ENSRNOT00000100087.2
      Conserved Domains (7) summary
      cd02897
      Location:969 → 1276
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:749 → 839
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:129 → 221
      A2M_N; MG2 domain
      pfam07677
      Location:1388 → 1475
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:457 → 607
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam17789
      Location:348 → 443
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:223 → 309
      MG3; Macroglobulin domain MG3

    5. XM_039107444.2 → XP_038963372.1  C3 and PZP-like, alpha-2-macroglobulin domain containing 8 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AG69
      Conserved Domains (6) summary
      cd02897
      Location:841 → 1148
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:621 → 711
      A2M; Alpha-2-macroglobulin family
      pfam07677
      Location:1260 → 1347
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:329 → 479
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam17789
      Location:220 → 315
      MG4; Macroglobulin domain MG4
      cl19929
      Location:129 → 161
      A2M_N; MG2 domain

    6. XM_039107443.2 → XP_038963371.1  C3 and PZP-like, alpha-2-macroglobulin domain containing 8 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AG69
      Conserved Domains (6) summary
      cd02897
      Location:848 → 1155
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:628 → 718
      A2M; Alpha-2-macroglobulin family
      pfam07677
      Location:1267 → 1354
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:336 → 486
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam17789
      Location:227 → 322
      MG4; Macroglobulin domain MG4
      cl19929
      Location:129 → 168
      A2M_N; MG2 domain

    7. XM_039107445.2 → XP_038963373.1  C3 and PZP-like, alpha-2-macroglobulin domain containing 8 isoform X7

      Conserved Domains (5) summary
      pfam00207
      Location:749 → 839
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:129 → 221
      A2M_N; MG2 domain
      pfam07703
      Location:457 → 607
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam17789
      Location:348 → 443
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:223 → 309
      MG3; Macroglobulin domain MG3
    Nucleotide Protein Strain
    Heading Accession and Version

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