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    Adat1 adenosine deaminase, tRNA-specific 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690810, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adat1provided by RGD
    Official Full Name
    adenosine deaminase, tRNA-specific 1provided by RGD
    Primary source
    RGD:1591020
    See related
    EnsemblRapid:ENSRNOG00000019434 AllianceGenome:RGD:1591020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity and tRNA-specific adenosine deaminase activity. Predicted to be involved in tRNA processing. Orthologous to human ADAT1 (adenosine deaminase tRNA specific 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 16.8), Adrenal (RPKM 16.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adat1 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (56825153..56866136, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (39918083..39956886, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (44172496..44212147, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene carbohydrate sulfotransferase 5 Neighboring gene transmembrane protein 231 Neighboring gene GABA type A receptor associated protein like 2 Neighboring gene lysyl-tRNA synthetase 1 Neighboring gene TERF2 interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes. Maas S, et al. Proc Natl Acad Sci U S A, 1999 Aug 3. PMID 10430867, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-specific adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA-specific adenosine deaminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tRNA-specific adenosine deaminase 1
    NP_001103081.1
    NP_001383775.1
    XP_006255697.1
    XP_006255698.1
    XP_006255700.1
    XP_008770757.2
    XP_038953929.1
    XP_038953931.1
    XP_063134368.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109611.2 → NP_001103081.1  tRNA-specific adenosine deaminase 1 isoform 1

      See identical proteins and their annotated locations for NP_001103081.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I6GI65, A6IZC1, D4ADL5
      Related
      ENSRNOP00000026309.3, ENSRNOT00000026309.7
      Conserved Domains (1) summary
      pfam02137
      Location:62 → 490
      A_deamin; Adenosine-deaminase (editase) domain

    2. NM_001396846.1 → NP_001383775.1  tRNA-specific adenosine deaminase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I6GI65
      Related
      ENSRNOP00000080487.2, ENSRNOT00000110420.2
      Conserved Domains (1) summary
      pfam02137
      Location:62 → 451
      A_deamin; Adenosine-deaminase (editase) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      56825153..56866136 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772535.4 → XP_008770757.2  tRNA-specific adenosine deaminase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZQD8, A0A8I6GI65
      Related
      ENSRNOP00000108371.1, ENSRNOT00000122018.1

    2. XM_063278298.1 → XP_063134368.1  tRNA-specific adenosine deaminase 1 isoform X5

    3. XM_039098003.1 → XP_038953931.1  tRNA-specific adenosine deaminase 1 isoform X4

      Conserved Domains (1) summary
      cl02661
      Location:62 → 245
      A_deamin; Adenosine-deaminase (editase) domain

    4. XM_006255635.5 → XP_006255697.1  tRNA-specific adenosine deaminase 1 isoform X1

      See identical proteins and their annotated locations for XP_006255697.1

      UniProtKB/TrEMBL
      A0A8I6GI65, A6IZC1, D4ADL5
      Conserved Domains (1) summary
      pfam02137
      Location:62 → 490
      A_deamin; Adenosine-deaminase (editase) domain

    5. XM_006255636.5 → XP_006255698.1  tRNA-specific adenosine deaminase 1 isoform X1

      See identical proteins and their annotated locations for XP_006255698.1

      UniProtKB/TrEMBL
      A0A8I6GI65, A6IZC1, D4ADL5
      Conserved Domains (1) summary
      pfam02137
      Location:62 → 490
      A_deamin; Adenosine-deaminase (editase) domain

    6. XM_039098001.2 → XP_038953929.1  tRNA-specific adenosine deaminase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GI65, A6IZC1, D4ADL5
      Conserved Domains (1) summary
      pfam02137
      Location:62 → 490
      A_deamin; Adenosine-deaminase (editase) domain

    7. XM_006255638.3 → XP_006255700.1  tRNA-specific adenosine deaminase 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GI65
      Conserved Domains (1) summary
      pfam02137
      Location:1 → 428
      A_deamin; Adenosine-deaminase (editase) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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