Uts2r urotensin 2 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Uts2rprovided by RGD
Official Full Name: urotensin 2 receptorprovided by RGD
Primary source: RGD:621884
See related: EnsemblRapid:ENSRNOG00000036669 AllianceGenome:RGD:621884
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Senr; Gpr14; UR-2-R
Summary: Enables urotensin II receptor activity. Involved in several processes, including positive regulation of vasoconstriction; regulation of blood pressure; and regulation of circadian sleep/wake cycle. Located in early endosome and recycling endosome. Used to study acute kidney failure; endomyocardial fibrosis; and hypertension. Biomarker of cardiomyopathy and myocardial infarction. Orthologous to human UTS2R (urotensin 2 receptor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 10q32.3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (106936398..106937558)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (106438092..106439252)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (110364291..110365451)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sterculia tragacantha Lindl Aqueous Leaf Extract Ameliorate Cardiomyopathy in Streptozotocin-induced Diabetic Rats via Urotensin II and FABP3 Expressions.
Title: Sterculia tragacantha Lindl Aqueous Leaf Extract Ameliorate Cardiomyopathy in Streptozotocin-induced Diabetic Rats via Urotensin II and FABP3 Expressions.
This study investigated possible role of U-II and its receptor expression in inflammation by using UTR agonist and antagonist in carrageenan induced acute inflammation
Title: Blocking of urotensin receptors as new target for treatment of carrageenan induced inflammation in rats.
Expression of GPR14 was increased at mRNA and protein levels in brain from cerebral ischemia rats.
Title: Expression of Urotensin II During Focal Cerebral Ischemic in Diabetic Rats.
The UII/UT system mediates upregulation of proinflammatory cytokines through p38 MAPK and NF-kappaB pathways in LPS-stimulated Kupffer cells.
Title: The UII/UT system mediates upregulation of proinflammatory cytokines through p38 MAPK and NF-κB pathways in LPS-stimulated Kupffer cells.
Key transmembrane domain 1 and 2 residues were identified in urotensin-II receptor (UT) that participate in the formation of the UT receptor binding pocket.
Title: Identification of transmembrane domain 1 & 2 residues that contribute to the formation of the ligand-binding pocket of the urotensin-II receptor.
Data show that vasoactive peptide urotensin II receptor and GABA(A)R are co-expressed in cerebellar glial cells from rat brain slices, in human native astrocytes and in glioma cell line.
Title: Down-regulation of GABA(A) receptor via promiscuity with the vasoactive peptide urotensin II receptor. Potential involvement in astrocyte plasticity.
The dynamic changes of urotensin II receptor in pulmonary arterioles might have an important contribution to the development of pulmonary hypertension and pulmonary arteriole remodeling induced by chronic hypoxia-hypercapnia in rats.
Title: [Dynamic changes of urotensin II receptor in pulmonary artery and arterioles of rats chronically exposed to hypoxia-hypercapnia].
we report a specific nuclear/perinuclear expression of the U-II receptor in the rat heart, which upon activation by U-II or URP results in different modulatory effects on transcription
Title: Biochemical and pharmacological characterization of nuclear urotensin-II binding sites in rat heart.
presence of functional nuclear UT in various rat and monkey tissues as well as in human cell lines
Title: Presence of urotensin-II receptors at the cell nucleus: specific tissue distribution and hypoxia-induced modulation.
The expression of U II and Uts2R in right ventricle arteries and right ventricle myocytes increases significantly during the formation of pulmonary hypertension and right ventricle hypertrophy in rats chronically exposed to hypoxia-hypercapnia.
Title: [Expression of Urotensin II and its receptor on right ventricle in rats of pulmonary hypertension].

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables urotensin II receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables urotensin II receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glomerular filtration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of urine volume	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of circadian sleep/wake cycle, REM sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of circadian sleep/wake cycle, wakefulness	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vasoconstriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: urotensin-2 receptor

Names: G-protein coupled receptor 14; G-protein coupled sensory epithelial neuropeptide-like receptor; UR-II-R; putative G protein-coupled receptor (SENR); urotensin II receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020537.1 → NP_065412.1 urotensin-2 receptor

See identical proteins and their annotated locations for NP_065412.1

Status: PROVISIONAL

Source sequence(s)

AB012210

UniProtKB/Swiss-Prot

P48041, P49684

UniProtKB/TrEMBL

A6HLM8

Related

ENSRNOP00000051809.1, ENSRNOT00000054926.3

Conserved Domains (1) summary

cd14999
Location:54 → 328

7tmA_UII-R; urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors