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    Accs 1-aminocyclopropane-1-carboxylate synthase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311218, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Accsprovided by RGD
    Official Full Name
    1-aminocyclopropane-1-carboxylate synthaseprovided by RGD
    Primary source
    RGD:1309314
    See related
    EnsemblRapid:ENSRNOG00000042533 AllianceGenome:RGD:1309314
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309314
    Summary
    Predicted to enable identical protein binding activity and transaminase activity. Predicted to be involved in amino acid metabolic process. Orthologous to human ACCS (1-aminocyclopropane-1-carboxylate synthase homolog (inactive)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 26.5), Liver (RPKM 24.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Accs in Genome Data Viewer
    Location:
    3q31
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (100261940..100276400, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (79805254..79820830, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (82742830..82757273, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ALX homeobox 4 Neighboring gene exostosin glycosyltransferase 2 Neighboring gene uncharacterized LOC120101603 Neighboring gene 1-aminocyclopropane-1-carboxylate synthase-like Neighboring gene ATP synthase membrane subunit c locus 1, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The human cDNA for a homologue of the plant enzyme 1-aminocyclopropane-1-carboxylate synthase encodes a protein lacking that activity. Koch KA, et al. Gene, 2001 Jul 11. PMID 11470512
    2. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Fragoza R, et al. Nat Commun, 2019 Sep 12. PMID 31515488, Free PMC Article
    3. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514
    4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables 1-aminocyclopropane-1-carboxylate synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    1-aminocyclopropane-1-carboxylate synthase-like protein 1
    Names
    1-aminocyclopropane-1-carboxylate synthase homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001267534.2 → NP_001254463.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8J8YIP6, A6HNJ5
      Related
      ENSRNOP00000012214.9, ENSRNOT00000012214.9
      Conserved Domains (1) summary
      PLN02450
      Location:35 → 475
      PLN02450; 1-aminocyclopropane-1-carboxylate synthase

    2. NM_001433376.1 → NP_001420305.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8J8YIP6, A6HNJ5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      100261940..100276400 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762028.4 → XP_008760250.2  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X1

      Conserved Domains (1) summary
      PLN02450
      Location:35 → 475
      PLN02450; 1-aminocyclopropane-1-carboxylate synthase

    2. XM_006234577.4 → XP_006234639.2  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8J8YIP6, A6HNJ5
      Conserved Domains (1) summary
      PLN02450
      Location:35 → 475
      PLN02450; 1-aminocyclopropane-1-carboxylate synthase

    3. XM_006234580.5 → XP_006234642.2  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8J8YIP6, A6HNJ5
      Conserved Domains (1) summary
      PLN02450
      Location:35 → 475
      PLN02450; 1-aminocyclopropane-1-carboxylate synthase

    4. XM_063283677.1 → XP_063139747.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X3

      UniProtKB/TrEMBL
      A6HNJ6

    5. XM_063283676.1 → XP_063139746.1  1-aminocyclopropane-1-carboxylate synthase-like protein 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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