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    Opn5 opsin 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316259, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Opn5provided by RGD
    Official Full Name
    opsin 5provided by RGD
    Primary source
    RGD:727869
    See related
    EnsemblRapid:ENSRNOG00000012689 AllianceGenome:RGD:727869
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gpr136
    Summary
    Predicted to enable 11-cis retinal binding activity and G protein-coupled photoreceptor activity. Predicted to be involved in several processes, including cellular response to UV; entrainment of circadian clock by photoperiod; and hyaloid vascular plexus regression. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human OPN5 (opsin 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human mouse all
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    Genomic context

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    See Opn5 in Genome Data Viewer
    Location:
    9q13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (25865610..25913315)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (18368393..18416098)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (21045457..21092517)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor F2 Neighboring gene adhesion G protein-coupled receptor F4 Neighboring gene transfer RNA threonine (anticodon AGU) 32 Neighboring gene patched domain containing 4 Neighboring gene uncharacterized LOC134480348

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of novel opsins and intrinsic light responses in the mammalian retinal ganglion cell line RGC-5. Presence of OPN5 in the rat retina. Nieto PS, et al. PLoS One, 2011. PMID 22022612, Free PMC Article
    2. UV-sensitive photoreceptor protein OPN5 in humans and mice. Kojima D, et al. PLoS One, 2011. PMID 22043319, Free PMC Article
    3. Evolution of mammalian Opn5 as a specialized UV-absorbing pigment by a single amino acid mutation. Yamashita T, et al. J Biol Chem, 2014 Feb 14. PMID 24403072, Free PMC Article
    4. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. Fredriksson R, et al. FEBS Lett, 2003 Nov 20. PMID 14623098
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The presence of Opn5 in the ganglion cell layer of the rat retina suggests the existence of a novel type of photoreceptor cell.
      Title: Expression of novel opsins and intrinsic light responses in the mammalian retinal ganglion cell line RGC-5. Presence of OPN5 in the rat retina.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 11-cis retinal binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G protein-coupled photoreceptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled photoreceptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to UV-A ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to light stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to light stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in detection of visible light IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in entrainment of circadian clock by photoperiod ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hyaloid vascular plexus regression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phototransduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phototransduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phototransduction, UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in photoreceptor outer segment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    opsin-5
    Names
    G protein-coupled receptor 136

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001389270.1 → NP_001376199.1  opsin-5

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5ZTV0, A6JJ51
      Related
      ENSRNOP00000080812.1, ENSRNOT00000106707.2
      Conserved Domains (1) summary
      cd15074
      Location:34 → 316
      7tmA_Opsin5_neuropsin; neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      25865610..25913315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083542.2 → XP_038939470.1  opsin-5 isoform X1

      UniProtKB/TrEMBL
      A0A8J8YD44, E9PTI9, Q7TQN6
      Related
      ENSRNOP00000030570.6, ENSRNOT00000031759.7
      Conserved Domains (1) summary
      cd15074
      Location:34 → 353
      7tmA_Opsin5_neuropsin; neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_181772.1: Suppressed sequence

      Description
      NM_181772.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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