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    Acp4 acid phosphatase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308569, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acp4provided by RGD
    Official Full Name
    acid phosphatase 4provided by RGD
    Primary source
    RGD:1308270
    See related
    EnsemblRapid:ENSRNOG00000021659 AllianceGenome:RGD:1308270
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Acpt
    Summary
    Predicted to enable acid phosphatase activity; protein tyrosine phosphatase activity; and receptor tyrosine kinase binding activity. Predicted to be involved in several processes, including negative regulation of ERBB4 signaling pathway; negative regulation of protein metabolic process; and regulation of neuronal synaptic plasticity. Located in postsynaptic membrane. Is active in glutamatergic synapse and synaptic membrane. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1J. Orthologous to human ACP4 (acid phosphatase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 76.2), Brain (RPKM 48.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Acp4 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (103872922..103888418, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (94736376..94751871, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100226311..100234536, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD88 Neighboring gene small nucleolar RNA, C/D box 88B Neighboring gene Friend virus susceptibility 1 Neighboring gene formyl peptide receptor-related sequence 4 Neighboring gene small integral membrane protein 47 Neighboring gene G protein-coupled receptor 32 Neighboring gene ribosome production factor 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Recessive Mutations in ACPT, Encoding Testicular Acid Phosphatase, Cause Hypoplastic Amelogenesis Imperfecta. Seymen F, et al. Am J Hum Genet, 2016 Nov 3. PMID 27843125, Free PMC Article
    2. Regulation of ErbB4 phosphorylation and cleavage by a novel histidine acid phosphatase. Fleisig H, et al. Neuroscience, 2004. PMID 15219672
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acid phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of ERBB4 signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of ERBB4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in odontogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuronal synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    testicular acid phosphatase
    Names
    acid phosphatase, testicular
    NP_001100980.2
    NP_001388455.1
    XP_008757591.1
    XP_038967846.1
    XP_038967865.1
    XP_038967876.1
    XP_038967884.1
    XP_063117957.1
    XP_063117984.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107510.2 → NP_001100980.2  testicular acid phosphatase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      Related
      ENSRNOP00000038370.6, ENSRNOT00000032200.7

    2. NM_001401526.1 → NP_001388455.1  testicular acid phosphatase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2KB67, A0A8I6GH32
      Related
      ENSRNOP00000089271.1, ENSRNOT00000094074.2
      Conserved Domains (1) summary
      cd07061
      Location:22 → 301
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      103872922..103888418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111937.2 → XP_038967865.1  testicular acid phosphatase isoform X2

      UniProtKB/TrEMBL
      A0A0G2KB67, A0A8I6GH32
      Conserved Domains (1) summary
      cd07061
      Location:22 → 301
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    2. XM_039111918.2 → XP_038967846.1  testicular acid phosphatase isoform X2

      UniProtKB/TrEMBL
      A0A0G2KB67, A0A8I6GH32
      Conserved Domains (1) summary
      cd07061
      Location:22 → 301
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    3. XM_063261887.1 → XP_063117957.1  testicular acid phosphatase isoform X1

      UniProtKB/TrEMBL
      A0A0G2KB67
      Related
      ENSRNOP00000075674.2, ENSRNOT00000079199.3

    4. XM_063261914.1 → XP_063117984.1  testicular acid phosphatase isoform X6

    5. XM_039111956.2 → XP_038967884.1  testicular acid phosphatase isoform X5

      Conserved Domains (1) summary
      cd07061
      Location:32 → 316
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    6. XM_039111948.2 → XP_038967876.1  testicular acid phosphatase isoform X4

      Conserved Domains (1) summary
      cd07061
      Location:32 → 316
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    7. XM_008759369.4 → XP_008757591.1  testicular acid phosphatase isoform X3

      UniProtKB/TrEMBL
      D4AD24
      Conserved Domains (1) summary
      cd07061
      Location:32 → 316
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    RNA

    1. XR_010052086.1 RNA Sequence

    2. XR_005505469.2 RNA Sequence

    3. XR_005505467.2 RNA Sequence

    4. XR_005505470.2 RNA Sequence

    5. XR_005505466.2 RNA Sequence

    6. XR_005505471.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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